LANNFELT, L and LILIUS, L and VIITANEN, M and HOULDEN, H and ROSSOR, M and HARDY, J and WINBLAD, B and BASUN, H (1995) MICROSATELLITE D21S210 (GT-12) ALLELE FREQUENCIES IN SPORADIC ALZHEIMERS-DISEASE. ACTA NEUROL SCAND , 91 (2) 145 - 148.
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Four disease-causing mutations have so far been described in the amyloid precursor protein gene on chromosome 21 in familial early-onset Alzheimer's disease. Linkage analysis with a fourteen-allele microsatellite at D21S210 named GT-12 has proven useful in the elucidation of amyloid precursor protein gene involvement in Alzheimer's disease families, as it is closely linked to the gene. Most cases of Alzheimer's disease are thought to be sporadic and not familial. However, evidence from earlier studies suggests an important genetic contribution also in sporadic cases, where gene-environment interaction may contribute to the disease. We have determined frequencies of the GT-12 alleles in 78 Swedish and 49 British sporadic Alzheimer's disease cases and 104 healthy elderly control subjects, to investigate if the disease associates with a particular genotype in GT-12. However, no differences in allele frequencies were observed between any of the groups.
|Title:||MICROSATELLITE D21S210 (GT-12) ALLELE FREQUENCIES IN SPORADIC ALZHEIMERS-DISEASE|
|Keywords:||ALZHEIMERS DISEASE, AMYLOID PRECURSOR PROTEIN (APP), CHROMOSOME 21, MICROSATELLITES, ASSOCIATION, GT- 12, PRECURSOR PROTEIN GENE, CEREBRAL-HEMORRHAGE, AMYLOID GENE, APP GENE, MUTATION, CHROMOSOME-14, LOCUS, MISSENSE, DEMENTIA, LINKAGE|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Molecular Neuroscience|
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Neurodegenerative Diseases
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