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Immunopathogenesis of SLE

Mason, LJ; Isenberg, DA; (1998) Immunopathogenesis of SLE. BAILLIERE CLIN RHEUM , 12 (3) 385 - 403.

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Abstract

Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disease characterized by the deposition of autoantibodies and immune complexes, leading to tissue damage. The immunopathogenesis of SLE is like a jigsaw puzzle, some pieces of which are missing or have not fallen into place. In predisposed individuals, the initial stimulus is likely to be one or more of the environmental agents interacting with susceptibility genes.Once the critical threshold is breached there is a failure of the immune system to downregulate the ensuing abnormal immune response, involving polyclonal B cell activation and hyperactive T cell help. Key questions include, what are the processes behind the availability of autoantigens and the breakdown of tolerance that give rise to the pathogenic autoantibodies? Current areas of research also involve the roles played by cytokines, adhesion molecules, cc-stimulatory molecules and apoptosis.

Type: Article
Title: Immunopathogenesis of SLE
Keywords: systemic lupus erythematosus, autoantibodies, immune complexes, cytokines, adhesion molecules, co-stimulation, apoptosis, SYSTEMIC LUPUS-ERYTHEMATOSUS, ANTI-DNA ANTIBODIES, T-CELL RECEPTORS, AUTOIMMUNE-DISEASE, ADHESION MOLECULES, NEPHRITIS, APOPTOSIS, AUTOANTIBODY, SPECIFICITY, EXPRESSION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: http://discovery.ucl.ac.uk/id/eprint/33624
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