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T-cell-depleted allogeneic bone marrow transplantation as postremission therapy for acute myelogenous leukemia: freedom from relapse in the absence of graft-versus-host disease

Papadopoulos, EB; Carabasi, MH; Castro-Malaspina, H; Childs, BH; Mackinnon, S; Boulad, F; Gillio, AP; ... Young, JW; + view all (1998) T-cell-depleted allogeneic bone marrow transplantation as postremission therapy for acute myelogenous leukemia: freedom from relapse in the absence of graft-versus-host disease. Blood , 91 (3) pp. 1083-1090.

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Type: Article
Title: T-cell-depleted allogeneic bone marrow transplantation as postremission therapy for acute myelogenous leukemia: freedom from relapse in the absence of graft-versus-host disease
Additional information: 98118226 Thirty-one consecutive patients with acute myelogenous leukemia (AML) in first complete remission and 8 with AML in second complete remission received T cell-depleted allogeneic bone marrow transplants from HLA- identical sibling donors. Patients received myeloablative cytoreduction consisting of hyperfractionated total body irradiation, thiotepa, and cyclophosphamide. Those patients at risk for immune-mediated graft rejection received additional immune suppression with antithymocyte globulin and methylprednisolone in the early peritransplant period. Patients with AML who underwent allogeneic T-cell-depleted bone marrow transplantations (BMT) in first or second remission have achieved respective disease-free survival (DFS) probabilities of 77% (median follow-up at approximately 56 months) and 50% (median follow-up at approximately 48 months). Ten of 31 patients transplanted in first remission were > or = 40 years old and have attained a DFS at 4 years of 70%. For patients with AML transplanted in first or second remission, the respective cause-specific probabilities of relapse were 3.2% or 12.5%, and those of nonleukemic mortality were 19.4% or 37.5%. There were no cases of immune-mediated graft rejection and no cases of grade II to IV acute graft-versus-host disease (GVHD). All survivors enjoy Karnofsky performance scores (KPS) of 100%, except 2 patients with KPS of 80% to 90%. T-cell-depleted allogeneic BMT can provide durable DFS together with an excellent performance status in the majority of patients with de novo AML. In addition, GVHD is not an obligatory correlate of the graft-versus-leukemia benefit or freedom from relapse afforded by allogeneic BMT administered as postremission therapy for AML. This study provides a basis for prospective comparison with other postremission therapies considered standard in the management of patients with this disease
Keywords: Adolescence, Adult, Antineoplastic Agents, Alkylating/therapeutic use, bone, BONE MARROW, Bone Marrow Purging, BONE MARROW TRANSPLANTATION, comparison, CYCLOPHOSPHAMIDE, Cyclophosphamide/therapeutic use, disease, Disease-Free Survival, Freedom, Herpesvirus 4, Human, hyperfractionated, Immunosuppressive Agents/therapeutic use, Leukemia, Myelocytic, Acute/Xtherapy, Lymphoproliferative Disorders/virology, management, Mortality, NOS, Patient, patients, Performance, Probability, Rejection, Remission Induction, Risk, support, non-u.s.gov't, support, u.s.gov't, p.h.s., Survival, Survivors, therapy, Thiotepa/therapeutic use, transplantation, Transplantation Chimera, transplants, Whole-Body Irradiation, XBone Marrow Transplantation/adverse effects, XGraft vs Host Disease, XT-Lymphocytes, XTreatment Outcome
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/33590
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