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Outcome of secondary myeloid malignancy in Hodgkin's disease: the BNLI experience

Harrison, CN; Hudson, GV; Devereux, S; Linch, DC; (1998) Outcome of secondary myeloid malignancy in Hodgkin's disease: the BNLI experience. EUR J HAEMATOL , 61 (2) 109 - 112.

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Abstract

In Hodgkin's disease where the majority of patients are long-term survivors secondary myeloid malignancies are a well-documented complication. The survival of those who develop secondary myelodysplasia/acute myeloid leukaemia (MDS/AML) is historically said to be extremely poor. This study from the BNLI database of over 4900 patients with Hodgkin's disease reports long-term follow-up of 30 patients with secondary MDS/AML. Five patients have survived at least 5 yr (1>12 yr) from the time of diagnosis of AML, These patients were significantly younger (p=0.03) than those who succumbed to this complication and each also had standard or favourable risk cytogenetics. The actuarial 5- and 10-yr survival rates are 17.4% (7.7-34.9%, 95% CI) and 8.7% (1.9-31.7%, 95% CI), respectively. There is therefore a subgroup of patients who will achieve long-term survival despite the development of secondary myeloid malignancy.

Type: Article
Title: Outcome of secondary myeloid malignancy in Hodgkin's disease: the BNLI experience
Keywords: Hodgkin's disease, secondary MDS/AML, outcome and BNLI, BONE-MARROW TRANSPLANTATION, THERAPY-RELATED LEUKEMIA, MYELODYSPLASTIC SYNDROME, LYMPHOMA, RISK
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/33585
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