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High-dose therapy for diffuse large-cell lymphoma in first remission

Perry, AR; Goldstone, AH; (1998) High-dose therapy for diffuse large-cell lymphoma in first remission. Annals of Oncology , 9 (1) S9-S14.

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Type: Article
Title: High-dose therapy for diffuse large-cell lymphoma in first remission
Additional information: 98242337 Diffuse large-cell lymphoma (DLCL) is curable by first-line conventional chemotherapy in 50%-60% of patients. High-dose therapy makes no contribution to this group of patients and, if applied indiscriminately as first-line consolidation therapy, is likely to unnecessarily increase overall morbidity and mortality. Instead, recent interest has been directed towards (a) the identification of a group of patients with a poor prognosis, and (b) the intensification of first- line treatment for such patients with high-dose therapy and allied regimens. Many prognostic factors have now been standardised, while studies are progressing in the identification of newer prognostic factors, such as the molecular markers. Multi-centre randomised trials are currently in progress to determine the appropriate level of treatment for prognostic subsets, with the value of high-dose therapy being assessed for those in the worst prognostic groups
Keywords: Antineoplastic Agents, Combined/administration & dosage/adverse effects/Xtherapeutic use, applied, B, Chemotherapy, Clinical Trials, Combined Modality Therapy, Drug Administration Schedule, Factors, groups, Hematopoietic Stem Cell Transplantation, identification, INCREASE, LINE, lymphoma, Lymphoma, Large-Cell, Diffuse/Xdrug therapy/mortality/radiotherapy/therapy, Morbidity, Mortality, Multicenter Studies, NOS, Patient, patients, Prognosis, Radiotherapy, Adjuvant, Randomized Controlled Trials, Remission Induction, Salvage Therapy, therapy, treatment, Treatment Outcome, TRIAL, TRIALS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/33580
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