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A case of EBV-associated lymphoproliferative disease following high-dose therapy and CD34-purified autologous peripheral blood progenitor cell transplantation

Peniket, AJ; Perry, AR; Williams, CD; MacMillan, A; Watts, MJ; Isaacson, PG; Goldstone, AH; (1998) A case of EBV-associated lymphoproliferative disease following high-dose therapy and CD34-purified autologous peripheral blood progenitor cell transplantation. BONE MARROW TRANSPL , 22 (3) 307 - 309.

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Abstract

A fatal case of EBV-associated lymphoproliferative disorder arising after a CD33-selected autologous peripheral blood stem cell transplant is reported in a patient with multiple myeloma in first plateau phase. It is suggested that this is likely to be a consequence of the accessory cell depletion associated with the CD34(+) cell purification and it is recommended that a source of autologous T cells is stored before transplantation to be used if a severe opportunistic infection or EBV lymphoma arises post-transplantation.

Type: Article
Title: A case of EBV-associated lymphoproliferative disease following high-dose therapy and CD34-purified autologous peripheral blood progenitor cell transplantation
Keywords: EBV-associated lymphoma, CD34 selection, myeloma, BONE-MARROW TRANSPLANTATION, NON-HODGKINS-LYMPHOMA, MULTIPLE-MYELOMA, MONOCLONAL-ANTIBODY, RANDOMIZED TRIAL, G-CSF, CHEMOTHERAPY, ANTIGEN, ENGRAFTMENT, CONTRIBUTE
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Pathology
URI: http://discovery.ucl.ac.uk/id/eprint/33503
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