Gane, PJ; Dean, PM; (2000) Recent advances in structure-based rational drug design. CURR OPIN STRUC BIOL , 10 (4) 401 - 404.
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Two approaches to structure-based drug design, that is, the docking of known compounds into a target protein and molecular assembly in situ, are seen to be merging technologies. The need for structural information about drug-protein complexes is now fundamental for drug discovery.
|Title:||Recent advances in structure-based rational drug design|
|Keywords:||PROTEIN-LIGAND INTERACTIONS, MOLECULAR DOCKING, INHIBITORS, POTENT, SIMULATION, DISCOVERY, PROGRAM|
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