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Resolution of AIDS-related Castleman's disease with anti-CD20 monoclonal antibodies is associated with declining IL-6 and TNF-alpha levels

Newsom-Davis, T; Bower, M; Wildfire, A; Thirlwell, C; Nelson, M; Gazzard, B; Stebbing, J; (2004) Resolution of AIDS-related Castleman's disease with anti-CD20 monoclonal antibodies is associated with declining IL-6 and TNF-alpha levels. LEUKEMIA LYMPHOMA , 45 (9) 1939 - 1941. 10.1080/10428190410001693533.

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Abstract

A 32-year-old HIV-1 positive man was diagnosed with Castleman's disease following a long history of constitutional symptoms. Primary therapy with single agent rituximab was associated with a near complete response. During this time, his KSHV (Kaposi's sarcoma-associated herpesvirus) viral load decreased and we also observed immediate, large and sustained decreases in interleukin-6 (IL-6) and tumor necrosis factor-alpha levels (TNF-alpha). This highlights the close association between circulating cytokines such as IL-6 and virally-induced malignancy.

Type: Article
Title: Resolution of AIDS-related Castleman's disease with anti-CD20 monoclonal antibodies is associated with declining IL-6 and TNF-alpha levels
DOI: 10.1080/10428190410001693533
Keywords: AIDS, Castleman's disease, cytokines, HIV, rituximab, SYSTEMIC LYMPHOPROLIFERATIVE DISORDER, HERPESVIRUS-ENCODED INTERLEUKIN-6, PRIMARY EFFUSION LYMPHOMA, KAPOSIS-SARCOMA, DNA-SEQUENCES, MORPHOLOGIC FEATURES, NODE HYPERPLASIA, HIV-INFECTION, VIRAL IL-6, HUMAN-HERPESVIRUS-8
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: http://discovery.ucl.ac.uk/id/eprint/320125
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