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Leptin levels in type 2 diabetes: associations with measures of insulin resistance and insulin secretion

Wauters, M; Considine, RV; Yudkin, JS; Peiffer, F; De, L; I, VG; L, F; (2003) Leptin levels in type 2 diabetes: associations with measures of insulin resistance and insulin secretion. Hormone and Metabolic Research , 35 (2) pp. 92-96.

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Interactions between leptin and insulin have been shown previously, in vitro and in vivo. In this study, we evaluate the associations of leptin levels with insulin secretion and insulin sensitivity in type 2 diabetes. Fasting leptin levels, HbA 1c, glucose, insulin, C-peptide, intact and des-31,32-proinsulin were measured in 100 non-insulin-treated type 2 diabetic patients. Glucose, insulin and C-peptide were measured 2 hours after an oral glucose load. Insulin resistance and beta-cell function were calculated using HOMA. Leptin levels were found to be associated with all measures of beta-cell secretion: with fasting and 2 hours insulin and C-peptide, with intact and des-31,32-proinsulin concentrations, and with beta-cell secretion estimated with HOMA. This association was independent of age and body fat in women, but in men, associations with insulin and C-peptide weakened after controlling for fat mass, whereas those with intact and des-31,32-proinsulin disappeared. Fasting insulin and C-peptide levels were also significant in multiple regression analyses, besides gender and fat mass. Insulin resistance, as assessed by HOMA, was strongly correlated with leptin, also after correction for age and fat mass in both genders. We conclude that, besides fat mass and gender - the main determinants for leptin levels in type 2 diabetic subjects as in healthy subjects - insulin secretion and the degree of insulin resistance also seem to contribute significantly to leptin levels

Type: Article
Title: Leptin levels in type 2 diabetes: associations with measures of insulin resistance and insulin secretion
Additional information: DA - 20030507 IS - 0018-5043 LA - eng PT - Journal Article RN - 0 (Blood Glucose) RN - 0 (C-Peptide) RN - 0 (Hypoglycemic Agents) RN - 0 (Leptin) RN - 11061-68-0 (Insulin) SB - IM
Keywords: Adipose Tissue, age, AGENT, AGENTS, anatomy & histology, As, Association, ASSOCIATIONS, BETA-CELL, Blood, Blood Glucose, bodies, body, Body Mass Index, C-Peptide, Comparative Study, Concentration, correction, DETERMINANT, DETERMINANTS, diabetes, Diabetes Mellitus, Type II, diabetic, Diabetic Diet, Fasting, FAT, Female, function, GENDER, Glucose, Glucose Tolerance Test, HEALTHY, Hypoglycemic Agents, IM, in vitro, in vivo, In-vitro, in-vivo, Insulin, Insulin Resistance, Insulin secretion, INSULIN SENSITIVITY, INSULIN-RESISTANCE, interaction, LA, Leptin, LEVEL, LOAD, Male, MASS, MEN, metabolism, Middle Aged, multiple, Oral, Patient, patients, physiopathology, REGRESSION, Resistance, secretion, Sensitivity, Sex Characteristics, Support, Non-U.S.Gov't, therapeutic use, TYPE-2, VITRO, vivo, WOMEN
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
URI: http://discovery.ucl.ac.uk/id/eprint/31469
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