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Three-dimensional distribution of radiation within the breast: An intercomparison of departments participating in the start trial of breast radiotherapy fractionation

Venables, K; Winfield, EA; Aird, EGA; Hoskin, PJ; (2003) Three-dimensional distribution of radiation within the breast: An intercomparison of departments participating in the start trial of breast radiotherapy fractionation. International Journal of Radiation Oncology Biology Physics , 55 (1) pp. 271-279.

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Abstract

Purpose: To examine the ability of computer planning systems to calculate the dose to the breast correctly in three dimensions. Both the absolute dose at the center of the breast and the accuracy of the isodose distributions were investigated. Methods and Materials: Measurements were performed in a water- filled breast phantom using an ionization chamber. Thirty-six sets of data obtained during the Standardization of Breast Radiotherapy breast fractionation trial quality assurance program were included in the analysis. The planning systems were grouped according to the algorithms used on the basis of the definitions given in International Commission on Radiation Units and Measurements Report No. 24. Results: Thirty-two of the 36 planning systems overestimated the dose to the center of the breast, with a mean measured/calculated dose ratio of 0.979 (SD 0.013). The relative dose within 2 cm of the lung was also overestimated. Conclusion: Only one algorithm (collapsed cone) investigated in this study was able to calculate the dose at the center of the breast correctly in tangential breast radiotherapy. With modern algorithms, it is important to include a correction for the lower density of the lung, because the dose close to the interface between breast and lung tissue will also be lower than anticipated. (C) 2003 Elsevier Science Inc

Type: Article
Title: Three-dimensional distribution of radiation within the breast: An intercomparison of departments participating in the start trial of breast radiotherapy fractionation
Additional information: Journal English Article ELSEVIER SCIENCE INC 0 JAN 1 647BD NEW YORK Venables K Mt Vernon Hosp, Dept Phys, Marie Curie Res Wing,Rickmansworth Rd, Northwood HA6 2RN, Middx, England INT J RADIAT ONCOL BIOL PHYS 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
Keywords: 3-DIMENSIONAL DOSE DISTRIBUTION, absolute, ALGORITHM, Algorithms, analysis, anthropomorphic phantom, Breast, breast dosimetry, CM, computer, CONVOLUTION, correction, DEFINITION, DENSITIES, DENSITY, distribution, Dosimetry, energy, English, interface, Ionization, IRRADIATION, Lung, Materials, measurement, MEASUREMENTS, Methods, MODELS, PENCIL BEAM KERNELS, PHANTOM, PHOTON BEAMS, PHYS, planning, PROGRAM, QUALITY, Quality assurance, radiation, Radiotherapy, radiotherapy treatment planning algorithms, RATIO, RD, report, Result, Science, SD, SOUTH, standardization, SYSTEM, SYSTEMS, Three-dimensional, Tissue, TRIAL, unit, UNITS, USA, Water
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: http://discovery.ucl.ac.uk/id/eprint/31427
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