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Associations of hip and thigh circumferences independent of waist circumference with the incidence of type 2 diabetes: the Hoorn Study.
American Journal of Clinical Nutrition
1192 - 1197.
BACKGROUND: The higher risk of type 2 diabetes in persons with a high waist-to-hip ratio (WHR) or waist-to-thigh ratio (WTR) has mostly been attributed to increased visceral fat accumulation. However, smaller hip or thigh circumference may also explain the predictive value of the WHR or WTR for type 2 diabetes. OBJECTIVE: This study considered prospectively the association of hip and thigh circumferences, independent of waist circumference, with the incidence of type 2 diabetes. DESIGN: The Hoorn Study is a population-based cohort study of diabetes. A total of 1357 men and women aged 50-75 y and nondiabetic at baseline participated in the 6-y follow-up examination. Glucose tolerance was assessed by use of a 75-g oral-glucose-tolerance test. Baseline anthropometric measurements included body mass index (BMI) and waist, hip, and thigh circumferences. RESULTS: Logistic regression analyses showed that a 1-SD larger hip circumference gave an odds ratio (OR) for developing diabetes of 0.55 (95% CI: 0.36, 0.85) in men and 0.63 (0.42, 0.94) in women, after adjustment for age, BMI, and waist circumference. The adjusted ORs for a 1-SD larger thigh circumference were 0.79 (0.53, 1.19) in men and 0.64 (0.46, 0.93) in women. In contrast with hip and thigh circumferences, waist circumference was positively associated with the incidence of type 2 diabetes in these models (ORs ranging from 1.60 to 2.66). CONCLUSION: Large hip and thigh circumferences are associated with a lower risk of type 2 diabetes, independently of BMI, age, and waist circumference, whereas a larger waist circumference is associated with a higher risk
|Title:||Associations of hip and thigh circumferences independent of waist circumference with the incidence of type 2 diabetes: the Hoorn Study|
|Additional information:||DA - 20030428 IS - 0002-9165 LA - eng PT - Journal Article SB - AIM SB - IM|
|Keywords:||Abdomen, ACCUMULATION, Adipose Tissue, adjustment, age, Aged, anatomy & histology, Association, ASSOCIATIONS, bodies, body, body composition, Body Constitution, Body Mass Index, COHORT, Cohort Studies, cohort study, Confidence Intervals, Cross-Sectional Studies, design, developing, diabetes, Diabetes Mellitus, Type II, epidemiology, etiology, FAT, Female, FOLLOW UP, Follow-up, Follow-Up Studies, Glucose, Glucose Tolerance Test, Hip, IM, Incidence, INDEX, LA, Logistic Regression, Male, MASS, May, measurement, MEASUREMENTS, MEN, Middle Aged, model, MODELS, Netherlands, Odds Ratio, predictive value, Prospective Studies, RATIO, REGRESSION, Result, Risk, Support, Non-U.S.Gov't, Thigh, tolerance, TYPE-2, Use, WOMEN|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)|
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