Donoghue, HD; Uberlaker, DH; Spigelman, M; (1999) The use of palaeomicrobiological techniques in a current forensic case. In: Pälfi, G and Dutour, O and Deák, J and Hutás, I, (eds.) Tuberculosis Past and Present. (363 - 368). Golden BookPublisher Ldt., Tuberculosis Foundation: Budapest.
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A human skeleton was sent for assessment by a law enforcement agency in the SW of the USA. Examination revealed this represented a young adult female, probably aged between 16-21 years. Soft tissue was absent, but time since death was difficult to determine precisely. Erosive and reactive skeletal lesions were present, suggestive of tuberculosis, although other diseases could not be ruled out. To verify if tuberculosis was present, which might assist in the identification of the remains, a sample of rib displaying evidence of disease was removed for analysis by PCR. The material from the bone sample clearly yielded Mycobacterium tuberculosis-complex-specific product so we conclude that the human remains were of an individual with tuberculosis, thus facilitating the on-going forensic investigation.
|Title:||The use of palaeomicrobiological techniques in a current forensic case|
|Keywords:||M. tuberculosis, PCR, ancient DNA, forensic, primers|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Infection and Immunity (Division of)|
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