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'Spontaneous' platelet aggregation in whole blood in diabetic patients with and without microvascular disease.

Hendra, TJ; Yudkin, JS; (1992) 'Spontaneous' platelet aggregation in whole blood in diabetic patients with and without microvascular disease. Diabet Med , 9 (3) pp. 247-251.

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Abstract

Consistent abnormalities of agonist-induced platelet aggregation, in either whole blood or platelet rich plasma, have not been demonstrated in diabetic patients without microvascular disease. In the present study platelet aggregation in the absence of exogenous agonists ('spontaneous' aggregation) was compared between 22 non-diabetic subjects and 23 Type 1 diabetic patients with (n = 12) and without (n = 11) microvascular disease. 'Spontaneous' aggregation was determined by measuring the percentage fall in single platelet number in aliquots of whole blood shaken for 60 min. Diabetic patients without microvascular disease had fewer single platelets remaining (greater aggregation) than non-diabetic subjects at all time-points (69.7 +/- 6.6 vs 82.3 +/- 7.3% at 60 min p less than 0.001), but more platelets remaining than in diabetic patients with microvascular disease at all time-points (69.7 +/- 6.6 vs 61.0 +/- 7.8% at 60 min p less than 0.02). No significant correlations were observed between platelet aggregation and plasma glucose, blood cell counts, or glycated haemoglobin levels. The study suggests that platelet abnormalities antedate the appearance of microvascular disease in diabetic patients.

Type: Article
Title: 'Spontaneous' platelet aggregation in whole blood in diabetic patients with and without microvascular disease.
Location: England
Keywords: Adult, Blood Glucose, Diabetes Mellitus, Type 1, Diabetic Angiopathies, Hematocrit, Hemoglobin A, Glycosylated, Humans, Leukocyte Count, Multivariate Analysis, Platelet Aggregation, Platelet Count, Reference Values
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
URI: http://discovery.ucl.ac.uk/id/eprint/30601
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