UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

A phase I/II study of CHARTWEL with concurrent chemotherapy in locally advanced, inoperable carcinoma of the oesophagus

Harney, J; Goodchild, K; Phillips, H; Glynne-Jones, R; Hoskin, PJ; Saunders, MI; (2003) A phase I/II study of CHARTWEL with concurrent chemotherapy in locally advanced, inoperable carcinoma of the oesophagus. Clinical Oncology , 15 (3) pp. 109-114.

Full text not available from this repository.

Abstract

Aim: To evaluate the feasibility, efficacy and toxicity of concurrent chemotherapy and continuous, hyperfractionated, accelerated radiotherapy weekend less (CHARTWEL) in the treatment of locally advanced, inoperable oesophageal cancer. Methods: A prospective study of 19 patients with histologically confirmed, locally advanced, inoperable carcinoma of the oesophagus. CHARTWEL was prescribed from day 1 to doses of 40.5 Gy (three patients), 42 Gy (five patients), 45 Gy (four patients), 46.5 Gy (three patients) and 49.5 Gy (four patients). Cisplatin 75 mg/m(2) was administered on day I of radiotherapy, followed by 5-fluorouracil (5-FU) 1000 mg daily for 4 days. Results: All patients completed radiotherapy, with two requiring modification of their chemotherapy dose. Acute toxicity was acceptable, with no interruptions to treatment. The median dysphagia free time was 9.6 months with 38% of patients being dysphagia free at 42 months. The median time to locoregional relapse was 13.2 months with 50% being free at I year and 35% at 3.5 years. There was a trend towards greater control when the higher doses (45-49.5 Gy) were compared with the lower doses (40.5-42 Gy), P = 0.07. The median survival time was 10.7 months with 1- and 2-year survival rates of 50 and 26%, respectively. Strictures developed in seven out of 18 patients (38%), but five were found on biopsy to be due to recurrent disease. There was no other long-term toxicity and no treatment-related death occurred. Conclusions: CHARTWEL with concomitant cisplatin/5-FU chemotherapy is a feasible treatment option in these patients. It is well tolerated, achieves a high rate of local control and effectively palliates the symptoms of dysphagia, all with relatively rapid resolution of treatment- related toxicity. The results warrant continued dose escalation to 51 Gy

Type: Article
Title: A phase I/II study of CHARTWEL with concurrent chemotherapy in locally advanced, inoperable carcinoma of the oesophagus
Additional information: Journal English Article ELSEVIER SCIENCE LONDON 0 MAY 674MG LONDON Harney J Mt Vernon Hosp, Marie Curie Res Wing,Rickmansworth Rd, Northwood HA6 2AE, Middx, England CLIN ONCOL-UK 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
Keywords: 5-Fluorouracil, ACCELERATED RADIOTHERAPY CHART, Biopsy, cancer, Carcinoma, CHARTWEL accelerated hyperfractionation, chemoradiation, Chemotherapy, Cisplatin, COMBINED CHEMORADIOTHERAPY, continuous, control, CONVENTIONAL RADIOTHERAPY, DEATH, DEVELOPED, disease, Dysphagia, EFFICACY, English, ESOPHAGEAL CANCER, INTERRUPTIONS, LESS, local, Local Control, LONG-TERM, LUNG-CANCER, May, Methods, MG, oesophageal cancer, Oesophagus, Other, Patient, patients, phase, Prospective Studies, prospective study, RADIATION- THERAPY, Radiotherapy, RANDOMIZED MULTICENTER TRIAL, RATES, RD, RECURRENT, RELAPSE, RESOLUTION, Result, Science, SQUAMOUS-CELL CARCINOMA, surgery, SURVIVAL, Survival Rate, SYMPTOM, SYMPTOMS, TIME, toxicity, treatment
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: http://discovery.ucl.ac.uk/id/eprint/30361
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item