UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Open-label, randomized study of pegfilgrastim vs. daily filgrastim as an adjunct to chemotherapy in elderly patients with non-Hodgkin's lymphoma

Grigg, A; Solal-Celigny, P; Hoskin, P; Taylor, K; McMillan, A; Forstpointner, R; Bacon, P; ... Hiddemann, W; + view all (2003) Open-label, randomized study of pegfilgrastim vs. daily filgrastim as an adjunct to chemotherapy in elderly patients with non-Hodgkin's lymphoma. Leukemia and Lymphoma , 44 (9) pp. 1503-1508.

Full text not available from this repository.

Abstract

Pegfilgrastim is composed of the protein filgrastim to which a 20-kDa polyethylene glycol (PEG) is covalently bound at the N- terminal residue resulting in decreased renal clearance and increased plasma half-life compared with filgrastim. This open- label, randomized, phase 2 study compared two doses of single administration pegfilgrastim (60 and 100 mug/kg) with daily doses of filgrastim (5 mug/kg/day) or no cytokine treatment after standard CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) chemotherapy for non-Hodgkin's lymphoma in 50 elderly patients. The primary endpoint was the duration of grade 4 (severe) neutropenia (absolute neutrophil count <0.5 x 10(9)/l) in cycle 1. Duration of grade 4 neutropenia in cycle 1 was 2.2 (SD 1.2), 1.5 (SD 1.1), 0.8 (1.2) and 5.0 (2.0) days for patients who received pegfilgrastim 60 &mu;g/kg, pegfilgrastim 100 &mu;g/kg, filgrastim 5 &mu;g/kg and no cytokine, respectively. The baseline characteristics of the pegfilgrastim and filgrastim groups were imbalanced with increased bone-marrow involvement and prior therapy in the former. When the treatment groups were balanced for these risk factors, duration of grade 4 neutropenia was comparable with 2.0 and 3.0 vs. 0.6 and 0.5 days for pegfilgrastim 100 &mu;g/kg and filgrastim patients with and without these risk factors, respectively. The incidence of febrile neutropenia (defined as ANC < 0.5 x 10(9)/l and temperature > 38.2degreesC) was low (10% of patients). Pegfilgrastim was well tolerated with a safety profile similar to daily filgrastim. Once per chemotherapy cycle administration of pegfilgrastim was comparable to filgrastim in this clinical setting

Type: Article
Title: Open-label, randomized study of pegfilgrastim vs. daily filgrastim as an adjunct to chemotherapy in elderly patients with non-Hodgkin's lymphoma
Additional information: Journal English Article TAYLOR & FRANCIS LTD 0 SEP 698NX ABINGDON Grigg A Royal Melbourne Hosp, Dept Clin Haematol & Oncol, Melbourne, Vic, Australia LEUK LYMPHOMA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
Keywords: absolute, Administration, As, Australia, Bone Marrow, BONE-MARROW, BREAST-CANCER, CELL LYMPHOMA, characteristics, Chemotherapy, CLEARANCE, clinical, COLONY-STIMULATING FACTOR, cycle, Cyclophosphamide, cytokine, dose intensity, Doxorubicin, DURATION, elderly, English, factors, febrile neutropenia, grade 4 neutropenia, groups, Incidence, INVOLVEMENT, LABEL, Low, Lymphoma, MULTICENTER, neutropenia, neutrophil, Non-Hodgkin's lymphoma, Patient, patients, phase, phase II clinical trial, PHASE-III, plasma, Prednisolone, PROGNOSTIC-SIGNIFICANCE, PROTEIN, randomized, renal, Risk, RISK FACTOR, Risk Factors, RISK-FACTORS, Safety, SD, Setting, SINGLE, SINGLE-ADMINISTRATION PEGFILGRASTIM, Temperature, therapy, treatment, Vincristine, VS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: http://discovery.ucl.ac.uk/id/eprint/30320
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item