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Direct demonstration of reduction of the output of the human motor cortex induced by a fatiguing muscle contraction

Di Lazzaro, V; Oliviero, A; Tonali, PA; Mazzone, P; Insola, A; Pilato, F; Saturno, E; ... Rothwell, JC; + view all (2003) Direct demonstration of reduction of the output of the human motor cortex induced by a fatiguing muscle contraction. EXP BRAIN RES , 149 (4) 535 - 538. 10.1007/s00221-003-1408-6.

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Abstract

A brief period of strong muscle contraction suppresses the amplitude of EMG responses evoked in relaxed muscle by transcranial magnetic stimulation (TMS) of the contralateral motor cortex. Here we investigate this phenomenon in more detail by recording the descending motor volleys evoked by TMS from electrodes in the cervical epidural space of three conscious patients implanted with chronic electrical stimulators for control of pain. We confirm that fatigue suppresses I waves evoked by TMS. In addition, D waves were suppressed in two of the patients, suggesting that axonal excitability might also be compromised by a period of intense muscle contraction.

Type: Article
Title: Direct demonstration of reduction of the output of the human motor cortex induced by a fatiguing muscle contraction
DOI: 10.1007/s00221-003-1408-6
Keywords: direct demonstration, human motor cortex, fatiguing muscle contraction, EMG response, transcranial magnetic stimulation, descending motor volley, TRANSCRANIAL MAGNETIC STIMULATION, HUMAN ELBOW FLEXORS, EVOKED-POTENTIALS, VOLUNTARY CONTRACTION, SUPRASPINAL FACTORS, CONSCIOUS HUMANS, PERIPHERAL-NERVE, DEPRESSION, EXERCISE, AXONS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/30075
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