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Prevalence of gastrointestinal diseases in two British national birth cohorts

Ehlin, AG; Montgomery, SM; Ekbom, A; Pounder, RE; Wakefield, AJ; (2003) Prevalence of gastrointestinal diseases in two British national birth cohorts. Gut , 52 (8) pp. 1117-1121.

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BACKGROUND: Few studies have investigated the prevalence of multiple gastrointestinal diseases in the general British population. AIM: To examine the prevalence of Crohn's disease (CD), ulcerative colitis (UC), irritable bowel syndrome (IBS), gall stones (GS), and peptic ulcer disease (PUD). SUBJECTS: The 1970 British Cohort Study (BCS70) and the National Child Development Study (NCDS) are two one week national birth cohorts born in 1970 and 1958, respectively. All cohort members living in Great Britain were interviewed in 1999/2000. METHODS: The prevalence rates of the five diseases were calculated, and associations with sex and childhood social class were investigated using logistic regression. RESULTS: At age 30 years, the prevalence rates per 10,000 (95% confidence interval (CI)) in the 1970 and 1958 cohorts, respectively, were: CD 38 (26-49), 21 (13-30); UC 30 (20-41), 27 (18-37); IBS 826 (775-877), 290 (267-330); GS 88 (71-106), 78 (62-94); and PUD 244 (214-273), 229 (201-256). There was a significantly higher proportion with CD (p=0.023) and IBS (p=0.000) in the 1970 cohort compared with the 1958 cohort at age 30 years. Comparing the cohorts in the 1999/2000 sweep, UC, GS, and PUD were significantly (p=0.001, p=0.000, p=0.000) more common in the 1958 cohort. There was a statistically significant trend for a higher risk of GS with lower social class in both cohorts combined (p=0.027). CONCLUSION: The study indicates an increasing temporal trend in the prevalence of CD and suggests a period effect in IBS, possibly due to adult life exposures or variation in recognition and diagnosis of IBS

Type: Article
Title: Prevalence of gastrointestinal diseases in two British national birth cohorts
Additional information: DA - 20030716 IS - 0017-5749 LA - eng PT - Journal Article SB - AIM SB - IM
Keywords: adolescent, adult, age, Age Distribution, Age of Onset, Association, ASSOCIATIONS, BIRTH, BORN, bowel, BRITAIN, British, Child, Child Development, childhood, Cholelithiasis, Class, COHORT, Cohort Studies, cohort study, colitis, Colitis, Ulcerative, Colonic Diseases, Functional, COMMON, confidence, Crohn Disease, Crohn's disease, development, diagnosis, disease, Diseases, epidemiology, EXPOSURE, Female, Gastrointestinal, Gastrointestinal Diseases, Great Britain, IB, IM, INDICATE, LA, LIFE, living, Logistic Models, Logistic Regression, Male, MEMBERS, Methods, multiple, NATIONAL BIRTH COHORT, Peptic Ulcer, population, Prevalence, RATES, recognition, REGRESSION, Regression Analysis, Result, Risk, Sex, social, Social Class, SOCIAL-CLASS, Support, Non-U.S.Gov't, Syndrome, Ulcer, ulcerative colitis, ULCERATIVE-COLITIS
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
URI: http://discovery.ucl.ac.uk/id/eprint/29845
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