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Endocytosis of anti-CCK-B/gastrin receptor antibody and effect on hepatoma cell lines

Stubbs, M; Khan, K; Watson, SA; Savage, K; Dhillon, AP; Caplin, ME; (2002) Endocytosis of anti-CCK-B/gastrin receptor antibody and effect on hepatoma cell lines. J HISTOCHEM CYTOCHEM , 50 (9) 1213 - 1217.

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Abstract

Immunotherapy has considerable potential in the treatment of cancer. Here we report on the uptake of an antibody raised against the CCK-B/Gastrin receptor (CCK-BR) by liver embryonic and liver tumor cell lines. In all five cell lines studied, expression of CCK-BR and uptake of labeled anti-CCK-BR antibody was observed. The labeled anti-CCK-BR antibody was localized in both the cytoplasm and nucleus of cells. In addition, we found a coincidence between the uptake of the labeled antibody by cells and the occurrence of apoptosis (cell death). The results suggest that antibodies directed against CCK-BR have potential for targeting and possibly destroying tumor cells bearing the receptor.

Type: Article
Title: Endocytosis of anti-CCK-B/gastrin receptor antibody and effect on hepatoma cell lines
Keywords: gastrin, CCK-B receptor, endocytosis, apoptosis, hepatocyte, tumor, HEPATOCELLULAR-CARCINOMA, GASTRIN, EXPRESSION, TUMOR, GROWTH
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
URI: http://discovery.ucl.ac.uk/id/eprint/29442
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