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The modification of human tumour blood flow using pentoxifylline, nicotinamide and carbogen

Sibtain, A; Hill, S; Goodchild, K; Shah, N; Saunders, M; Hoskin, PJ; (2002) The modification of human tumour blood flow using pentoxifylline, nicotinamide and carbogen. Radiotherapy And Oncology , 62 (1) pp. 69-76.

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Abstract

Aim: To assess the effect of combining oral nicotinamide, oral pentoxifylline and carbogen gas (2% CO2, 98% O-2) breathing on human tumour red cell flux. Methods and materials: Microregional red blood cell flux was measured in accessible tumour nodules using laser Doppler microprobes in 11 patients with histologically proven malignancy. Patients received single oral doses of nicotinamide 40 mg kg(-1) and pentoxifylline 1200 m(-2) h before a 10-min period of carbogen gas breathing, corresponding to peak plasma concentrations of these drugs. Red cell flux in up to six microregions in each tumour was measured for 30 min, recording pre-, during and post-carbogen breathing for 10 min each. Results: Data from ten of the 11 patients could be assessed. The red cell flux in 48 microregions was analysed and the mean red cell flux was calculated. A mean relative increase in red cell flux of 1.18 (+/-0.09, 95% confidence interval (CI)) was observed after 6 min of carbogen breathing, 2 h after the administration of nicotinamide and pentoxifylline. This compares to relative increases of 1.4 (+/- 0.39, 95% CI) after nicotinamide with carbogen and 1.15 (+/- 0.10, 95% CI) after pentoxifylline with carbogen. These differences are not statistically significant (P>0.05). The increased red cell flux persisted after the cessation of carbogen gas breathing Conclusions: A combination of pentoxifylline, nicotinamide and carbogen produces an increase in human tumour red cell flux, similar to that observed when each of the drugs are used alone with carbogen breathing. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved

Type: Article
Title: The modification of human tumour blood flow using pentoxifylline, nicotinamide and carbogen
Additional information: Journal English Article ELSEVIER SCI IRELAND LTD JAN 524PC CLARE Hoskin PJ Mt Vernon Hosp, Marie Curie Res Wing, Rickmansworth Rd, Northwood HA6 2RN, Middx, England RADIOTHER ONCOL CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND
Keywords: 1200, ACCELERATED RADIOTHERAPY, accessible, Administration, Blood, blood flow, BLOOD-FLOW, breathing, cancer, carbogen, cell, CELL DEFORMABILITY, CO, COMBINATION, Concentration, confidence, confidence interval, difference, DIOXIDE, DOPPLER, dose, DRUG, DRUGS, English, flow, GA, GAS, HEARING-LOSS, human tumours, hypoxia, INCREASE, INCREASES, industrial, Ireland, Laser, MALIGNANCIES, Malignancy, Manager, Materials, Methods, MG, Microprobes, murine, nicotinamide, Oral, Oxygenation, Patient, patients, pentoxifylline, Perfusion, plasma, PLASMA-CONCENTRATIONS, RADIATION RESPONSE, RD, Relative, Result, rights, Science, SINGLE, Tumour
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: http://discovery.ucl.ac.uk/id/eprint/29368
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