Sander, T and Windemuth, C and Schulz, H and Saar, K and Gennaro, E and Bianchi, A and Zara, F and Bulteau, C and Kaminska, A and Ville, D and Cieuta, C and Prud'homme, JF and Dulac, O and Bate, L and Gardiner, RM and de Haan, GJ and Janssen, GA and Witte, J and Halley, DJ and Lindhout, D and Wienker, TF and Janz, D (2002) No evidence for a susceptibility locus for idiopathic generalized epilepsy on chromosome 18q21.1. American Journal of Medical Genetics Part A , 114 (6) 673 - 678.
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A recent genome-wide scan showed strong evidence for a major locus for common syndromes of idiopathic generalized epilepsy (IGE) at the marker D18S474 on chromosome 18q21.1 (LOD score 4.5/5.2 multipoint/two-point). The present replication study tested the presence of an IGE locus in the chromosomal region 18q21.1. Our linkage study included 130 multiplex families of probands with common IGE syndromes. Eleven microsatellite polymorphisms encompassing a candidate region of 30 cM on either side of the marker D18S474 were genotyped. The two-point homogeneity LOD score for D18S474 showed strong evidence against linkage at the original linkage peak (Z = -18.86 at theta(m = f) = 0.05), assuming a recessive mode of inheritance with 50% penetrance. Multipoint parametric heterogeneity LOD scores < -2 were obtained along the candidate region when proportions of linked families greater than 35% were assumed under recessive inheritance. Furthermore, non-parametric multipoint linkage analyses showed no hint of linkage throughout the candidate region (P > 0.19). Accordingly, we failed to support evidence for a major IGE locus in the chromosomal region 18p11-18q23. If there is a susceptibility locus for IGE in this region then the size of the effect or the proportion of linked families is too small to detect linkage in the investigated family sample
|Title:||No evidence for a susceptibility locus for idiopathic generalized epilepsy on chromosome 18q21.1|
|Additional information:||UI - 22196779 DA - 20020904 IS - 0148-7299 LA - eng PT - Journal Article CY - United States RN - 0 (Genetic Markers) SB - IM|
|Keywords:||CHROMOSOME, CM, COMMON, Epilepsy, families, family, GENERALIZED EPILEPSY, genetic, Genetic Markers, genetics, Heterogeneity, idiopathic, Ige, IM, INHERITANCE, LA, Linkage, LOCUS, Lod Score, MARKER, Markers, MICROSATELLITE, Neurogenetics, NO EVIDENCE, parametric, Penetrance, Polymorphism, polymorphisms, PROBANDS, REGION, REPLICATION, SAMPLE, SCAN, SCORES, size, small, STATE, STATES, support, SUSCEPTIBILITY, Syndrome, united, United States, UNITED-STATES|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Child Health|
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