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The ingestion of inorganic nitrate increases gastric S-nitrosothiol levels and inhibits platelet function in humans

Richardson, G; Hicks, SL; O'Byrne, S; Frost, MT; Moore, K; Benjamin, N; McKnight, GM; (2002) The ingestion of inorganic nitrate increases gastric S-nitrosothiol levels and inhibits platelet function in humans. Nitric Oxide - Biology and Chemistry , 7 (1) pp. 24-29. 10.1016/S1089-8603(02)00010-1.

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Abstract

Platelets play an important role in the development of vascular disease, while vegetarian diets, which are rich in inorganic nitrate, protect against it. This study was performed to assess the effect of potassium nitrate (KNO3) ingestion on platelet function in humans. Oral KNO3 (2 mmol) was given to healthy volunteers and its effect on platelet function assessed by measuring the aggregant effect of collagen. Blood samples were taken for measurement of plasma S-nitrosothiols (RSNO) and platelet cyclic GMP and nitrotyrosine levels. Gastric juice samples were taken for measurement of RSNO. In a separate study, the effect of oral KNO3 on portal RSNO levels in patients with intrahepatic porto-systemic shunts was assessed. KNO3 caused a significant increase in gastric RSNO levels, from 0.46 ± 0.06 to 3.62 ± 2.82 μM (tmax 45 min; P < 0.001), and significantly inhibited platelet function (tmax 60 min; P < 0.001). There was no effect on systemic or portal RSNO, platelet cGMP or platelet nitrotyrosine levels. Oral KNO3 inhibits platelet aggregation. The time course suggests that gastric RSNO production may be involved in this effect. The protection against vascular events associated with a high intake of vegetables may be due to their high nitrate content. © 2002 Elsevier Science (USA). All rights reserved.

Type: Article
Title: The ingestion of inorganic nitrate increases gastric S-nitrosothiol levels and inhibits platelet function in humans
DOI: 10.1016/S1089-8603(02)00010-1
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
URI: http://discovery.ucl.ac.uk/id/eprint/29172
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