Randeva, HS and Davison, R and Chamoun, V and Bouloux, PM (2002) Isolated neurosarcoidosis--a diagnostic enigma: case report and discussion. Endocrine , 17 (3) 241 - 247.
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Abstract
Neurosarcoidosis is a rare, but well-recognized cause of hypopituitarism with a predilection for the hypothalamus. We describe a case of panhypopituitarism in a 57-yr-old Asian lady, associated with an infiltrating hypothalamo-hypophyseal lesion, and other intracranial deposits, initially diagnosed as cerebral tuberculomata. Despite antituberculous therapy, the intracranial lesions progressed with significant clinical deterioration. Repeated lumbar puncture, magnetic resonance imaging scans, liver biopsy and Gallium scan were noncontributory, and the diagnosis of isolated neurosarcoidosis was established only following biopsy of an intracranial lesion. The lesion regressed on steroid and azathioprine therapy. Isolated neurosarcoidosis poses a considerable management problem. We review recent advances in the investigation, diagnosis, and treatment of this condition
| Type: | Article |
|---|---|
| Title: | Isolated neurosarcoidosis--a diagnostic enigma: case report and discussion |
| Additional information: | UI - 22100842 DA - 20020710 IS - 0969-711X LA - eng PT - Journal Article RN - 0 (Antimetabolites) RN - 446-86-6 (Azathioprine) RN - EC 3.4.15.1 (Peptidyl-Dipeptidase A) SB - IM |
| Keywords: | ACE, advances, ANGIOTENSIN-CONVERTING ENZYME, As, Asian, Azathioprine, Biopsy, case report, CENTRAL-NERVOUS-SYSTEM, Cerebral, CEREBROSPINAL-FLUID, clinical, Condition, CSF, DEPOSITS, diagnosis, endocrine, English, gallium, Hypopituitarism, Hypothalamus, imaging, lesion, Lesions, liver, Liver Biopsy, LUMBAR, Magnetic, MAGNETIC RESONANCE, Magnetic Resonance Imaging, MAGNETIC-RESONANCE, Management, MANIFESTATIONS, MRI, neurosarcoidosis, Other, PRESS, PROGRESS, Puncture, Recent Advances, report, resonance, Resonance imaging, Review, Sarcoidosis, SCAN, SCANS, Steroid, THERAPIES, therapy, treatment, USA, advances, Antimetabolites, CEREBROSPINAL FLUID, EC, Female, IM, LA, Leukocyte Count, metabolism, Middle Age, Nervous System Diseases, pathology, Peptidyl-Dipeptidase A, radionuclide imaging, therapeutic use |
| UCL classification: | UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of) > Metabolism and Experimental Therapeutics |
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