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Pharmacokinetics and anticonvulsant effects of diazepam in children with severe falciparum malaria and convulsions.
British Journal of Clinical Pharmacology
49 - 57.
AIMS: Convulsions are a common complication of severe malaria in children and are associated with poor outcome. Diazepam is used to terminate convulsions but its pharmacokinetics and pharmacodynamics have not been studied in this group. Accordingly, we carried out a comparative study of the pharmacokinetics of intravenous (i.v.) and rectal (p.r.) diazepam. METHODS: Twenty-five children with severe malaria and a convulsion lasting >5 min were studied. Sixteen children received diazepam intravenously (i.v.; 0.3 mg kg(-1)) and nine rectally (p.r.; 0.5 mg kg(-1)). Plasma diazepam concentrations were measured by reversed phase high-performance liquid chromatography. The duration of convulsions, depth of coma, respiratory and cardiovascular parameters were monitored. RESULTS: Median maximum plasma diazepam concentrations of 634 (range 402-1507) ng ml(-1) and 423 (range 112-1953) ng ml(-1) were achieved at 5 and 25 min following i.v. and p.r. administration, respectively. All patients except three (one i.v. and two p.r.) achiev
|Title:||Pharmacokinetics and anticonvulsant effects of diazepam in children with severe falciparum malaria and convulsions|
|Additional information:||UI - 21838046 LA - eng RN - 0 (Anticonvulsants) RN - 439-14-5 (Diazepam) PT - Journal Article DA - 20020218 IS - 0306-5251 SB - IM CY - England|
|Keywords:||Administration, administration & dosage, Administration, Rectal, Anticonvulsants, Area Under Curve, Blood, cardiovascular, Child, Preschool, children, Chromatography, Coma, COMMON, Comparative Studies, Comparative Study, COMPLICATION, complications, Concentration, Convulsions, Depth, Diazepam, drug therapy, DURATION, effects, etiology, falciparum Malaria, Female, IM, infant, Infusions, Intravenous, INTRAVENOUS, LA, liquid, liquid chromatography, LIQUID-CHROMATOGRAPHY, Malaria, Malaria, Falciparum, Male, Methods, MG, outcome, PARAMETER, PARAMETERS, Patient, patients, pharmacodynamics, pharmacokinetic, Pharmacokinetics, phase, plasma, poor, RANGE, Regression Analysis, RESPIRATORY, Result, REVERSED-PHASE, Statistics, Nonparametric, Support, Non-U.S.Gov't|
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