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Transgenic models of tolerance and autoimmunity: with special reference to systemic lupus erythematosus

Ravirajan, CT; Isenberg, DA; (2002) Transgenic models of tolerance and autoimmunity: with special reference to systemic lupus erythematosus. LUPUS , 11 (12) 843 - 849. 10.1191/0961203302lu305rr.

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Abstract

Transgenic and knockout mouse carrying rearranged antigen-receptor genes have been invaluable for the elucidation of basic mechanisms in autoimmunity and have contributed new models of human autoimmune diseases. Several examples of transgenic models expressing rearranged immunoglobulin genes have been described. These models have provided a window into the events involved in this process, allowing the development and fate of self-reactive lymphocytes to be followed in vivo. In the B cell lineage, as in T cells, self-reactive cells have been found to undergo several distinct fates in vivo: they can be physically eliminated, functionally inactivated, or they can persist unchanged or become activated. Nevertheless the precise understanding of the molecular events leading to lymphocyte deletion, anergy or activation remains a challenge.

Type: Article
Title: Transgenic models of tolerance and autoimmunity: with special reference to systemic lupus erythematosus
DOI: 10.1191/0961203302lu305rr
Keywords: autoimmunity, anti-DNA antibodies, transgenic models, tolerance, pathogenicity, REACTIVE B-CELLS, SELF-NONSELF DISCRIMINATION, ANTI-DNA ANTIBODIES, LYMPHOCYTES-B, MURINE LUPUS, HEAVY-CHAIN, T-CELLS, MICE, GENE, RECEPTOR
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: http://discovery.ucl.ac.uk/id/eprint/28919
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