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International consensus on palliative radiotherapy endpoints for future clinical trials in bone metastases

Chow, E; Wu, JSY; Hoskin, P; Coia, LR; Bentzen, SM; Blitzer, PH; (2002) International consensus on palliative radiotherapy endpoints for future clinical trials in bone metastases. Radiotherapy And Oncology , 64 (3) pp. 275-280.

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Abstract

Purpose: To reach a consensus on a set of optimal endpoint measurements for future external beam radiotherapy trials in bone metastases. Methods: An International Bone Metastases Consensus Working Party invited principal investigators and individuals with a recognized interest in bone metastases to participate in the two surveys and a panel meeting on their preference of choice of optimal endpoints. Results: Consensus has been reached on the following: (a) eligibility criteria for future trials; (b) pain and analgesic assessments; (c) radiation techniques; (d) follow-up and timing of assessments; (e) parameters at follow-up; (f) endpoints; (g) re-irradiation; and (h) statistical analysis. Conclusions: Based on the available literature and the clinical experience of the working party members, an acceptable set of endpoints has been agreed upon for future clinical trials to promote consistency in reporting. It is intended that the consensus will be re- examined every 5 years. Areas of further research were identified. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved

Type: Article
Title: International consensus on palliative radiotherapy endpoints for future clinical trials in bone metastases
Additional information: Journal English Article ELSEVIER SCI IRELAND LTD SEP 610YB CLARE Chow E Univ Toronto, Dept Radiat Oncol, Toronto Sunnybrook Reg Canc Ctr, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada RADIOTHER ONCOL CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND
Keywords: analysis, assessment, bone, bone metastases, BREAST-CANCER, Canada, CANCER-PATIENTS, CHOICE, clinical, clinical experience, Clinical trial, Clinical Trials, CLINICAL-EXPERIENCE, CLINICAL-TRIAL, CLINICAL-TRIALS, CO, Consensus, CRITERIA, E, English, EXPERIENCE, FIXATION, FOLLOW UP, Follow-up, future, future clinical trials, individuals, industrial, international consensus, Ireland, KARNOFSKY PERFORMANCE STATUS, literature, LONG BONES, Manager, measurement, MEASUREMENTS, MEMBERS, METASTASES, Methods, optimal, pain, palliative, palliative radiotherapy endpoints, panel, PARAMETER, PARAMETERS, PROSPECTIVE RANDOMIZED TRIAL, radiation, RADIATION-THERAPY, Radiotherapy, Research, Result, rights, SCHEDULES, Science, SINGLE, Statistical analysis, Survey, Surveys, technique, techniques, TRIAL, TRIALS
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: http://discovery.ucl.ac.uk/id/eprint/28063
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