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Evaluation of good clinical response to neoadjuvant chemotherapy in primary breast cancer using [F-18]- fluorodeoxyglucose positron emission tomography

Burcombe, RJ; Makris, A; Pittam, M; Lowe, J; Emmott, J; Wong, WL; (2002) Evaluation of good clinical response to neoadjuvant chemotherapy in primary breast cancer using [F-18]- fluorodeoxyglucose positron emission tomography. European Journal of Cancer , 38 (3) pp. 375-379.

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Abstract

To determine whether [F-18]-fluorodeoxyglucose (FDG) positron emission tomography (PET) can predict complete pathological response (pCR) in patients achieving a good clinical response to neoadjuvant chemotherapy for primary breast cancer, 10 patients underwent FDG PET scanning prior to definitive breast surgery. Scan reports were compared with histopathological findings. No abnormal uptake at the primary tumour site was visualised in any patient. 9 of the 10 patients had residual invasive carcinoma at operation, ranging from 2 to 20 mm in maximum dimension. One patient achieved a complete pathological response. Of the 5 patients who underwent axillary surgery, no axillary FDG uptake was seen preoperatively although 3 of the 5 were histologically node-positive. FDG PET did not reliably identify residual disease in this series of good clinical responders to neoadjuvant chemotherapy, and its discriminatory power as a tool to predict complete pathological response therefore appears to be inadequate for clinical use in this setting. (C) 2002 Elsevier Science Ltd. All rights reserved

Type: Article
Title: Evaluation of good clinical response to neoadjuvant chemotherapy in primary breast cancer using [F-18]- fluorodeoxyglucose positron emission tomography
Additional information: Journal English Article PERGAMON-ELSEVIER SCIENCE LTD FEB 522QE OXFORD Makris A Mt Vernon Hosp, Marie Curie Res Wing,Rickmansworth Rd, Northwood HA6 2RN, Middx, England EUR J CANCER THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
Keywords: abnormal, As, Breast, BREAST CANCER, breast neoplasms/drug therapy fluorodeoxyglucose F 18/diagnostic use tomography, breast neoplasms/pathology, breast neoplasms/radionuclide imaging, BREAST-CANCER, cancer, Carcinoma, Chemotherapy, clinical, combined/therapeutic use, Complete, discriminatory, disease, emission, emission- computed/methods antineoplastic agents, English, evaluation, F-18 FLUORODEOXYGLUCOSE, FDG, FDG-PET, Glucose, histopathological, MM, OPERATION, OXFORD, PATHOLOGICAL RESPONSE, Patient, patients, PCR, PET, PET Scanning, Positron, Positron Emission Tomography, POSITRON-EMISSION-TOMOGRAPHY, power, Predictive Value of Tests, PREOPERATIVE CHEMOTHERAPY, RD, report, Reports, response, rights, SCAN, Science, SERIES, Setting, SITE, surgery, therapy, tomography, TOOL, Tumour, uptake, Use, WOMEN
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: http://discovery.ucl.ac.uk/id/eprint/27983
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