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Elevated C-reactive protein and pro-inflammatory cytokines in Andean women with pre-eclampsia

Teran, E; Escudero, C; Moya, W; Flores, M; Vallance, P; Lopez-Jaramillo, P; (2001) Elevated C-reactive protein and pro-inflammatory cytokines in Andean women with pre-eclampsia. International Journal of Gynecology and Obstetrics , 75 (3) 243 - 249.

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Abstract

OBJECTIVE: To investigate the concentration of markers of inflammation in non-pregnant women, women with normal pregnancy and women with pre- eclampsia. METHODS: Pregnant women (n=26), women with pre-eclampsia (n=25) and non-pregnant normotensive women (n=21) were included in the study. C-reactive protein was measured by latex-enhanced immunoturbidimetric assay, serum tumor necrosis factor-alpha (TNF- alpha) and interleukin-6 (IL-6) by high sensitivity ELISA. Kruskal- Wallis non-parametric analysis of variance followed by the Mann-Whitney U-test were used for statistical analyses. RESULTS: Higher values (mean+/-S.E.M.) of C-reactive protein were found in pre-eclampsia (4.11+/-0.37 mg/dl) compared with normal pregnant women (2.49+/-0.26 mg/dl) and non-pregnant controls (1.33+/-0.15 mg/dl). TNF-alpha was significantly higher in women with pre-eclampsia (15.74+/-5.09 pg/ml), in relation to the control group (2.76+/-0.41 pg/ml) and women with normal pregnancy (8.31+/-1.55 pg/ml). IL-6 levels were significantly higher in pre-eclamptic women (12.91+/-1.29 pg/ml) compared with normal pregnant (5.07+/-0.423 pg/ml) and control women (1.25+/-0.13 pg/ml). CONCLUSIONS: The results of this cross-sectional study in a high-risk Andean population show that both C-reactive protein and pro- inflammatory cytokines are present in higher concentrations in women with pre-eclampsia. The study was undertaken in women with established pre-eclampsia and it is not possible to determine whether the increased concentrations of C-reactive protein and pro-inflammatory cytokines were a cause or consequence of the disease

Type:Article
Title:Elevated C-reactive protein and pro-inflammatory cytokines in Andean women with pre-eclampsia
Additional information:UI - 21585813 LA - eng RN - 0 (Interleukin-6) RN - 0 (Tumor Necrosis Factor) RN - 9007-41-4 (C-Reactive Protein) PT - Journal Article DA - 20011130 IS - 0020-7292 SB - IM CY - Ireland
Keywords:adult, ALPHA, analysis, Analysis of Variance, ASSAY, Blood, Blood Pressure, C REACTIVE PROTEIN, C-Reactive Protein, C-REACTIVE-PROTEIN, Concentration, control, Cross Sectional Studies, Cross-Sectional Studies, cytokine, Cytokines, disease, Ecuador, ELISA, Enzyme-Linked Immunosorbent Assay, FACTOR ALPHA, FACTOR-ALPHA, Female, Gestational Age, HIGH-RISK, IL-6, IM, Inflammation, inflammatory cytokines, Interleukin 6, Interleukin-6, Ireland, LA, Leukocyte Count, LEVEL, MARKER, Markers, Methods, necrosis, NECROSIS-FACTOR-ALPHA, objective, parity, population, pre-eclampsia, Preeclampsia, PREGNANCIES, Pregnancy, PREGNANT, PRO, PROINFLAMMATORY CYTOKINE, PROINFLAMMATORY CYTOKINES, PROTEIN, Research, Result, Sensitivity, SERA, serum, Support, Non-U.S.Gov't, TNF, TNF ALPHA, TNF-ALPHA, Tumor, tumor necrosis, Tumor Necrosis Factor, Tumor Necrosis Factor Alpha, tumor necrosis factor-alpha, TUMOR-NECROSIS-FACTOR, VALUES, WOMEN
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)

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