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Nitric oxide: not just a negative inotrope

Sarkar, D; Vallance, P; Harding, SE; (2001) Nitric oxide: not just a negative inotrope. European Journal of Heart Failure , 3 (5) pp. 527-534.

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Nitric oxide (NO) appears to play a role in modulating cardiac function in both health and disease. Early studies in isolated rodent cardiac myocytes demonstrated a depressant effect of NO supplied by NO donors (exogenous) as well as NO generated within myocytes (endogenous). There is increasing evidence for a functional NO generating system within the human myocardium, which appears upregulated in certain disease states. Induction of the high output nitric oxide synthase isoform (iNOS) has been demonstrated in the failing myocardium, though its functional significance remains unproven. More recently published data have contradicted the notion that NO acts solely as a negative inotrope demonstrating positive inotropy in both isolated rodent and human ventricular myocytes in response to a range of NO donors. Different NO donors have different NO release kinetics and generate a range of NO species (NO., NO+ and NO-) which may interact at a number of subcellular targets. The observed response of any cardiac preparation to an NO donor represents the net effect of activation of different effector targets and may explain the contradictory reported effects of NO. To realise the therapeutic potential of NO will require specific targeting at a subcellular level

Type: Article
Title: Nitric oxide: not just a negative inotrope
Additional information: UI - 21479352 LA - eng RN - 0 (Nitric Oxide Donors) RN - 10102-43-9 (Nitric Oxide) RN - EC 1.14.13.- (inducible nitric oxide synthase) RN - EC (Nitric-Oxide Synthase) PT - Journal Article PT - Review PT - Review, Tutorial DA - 20011011 IS - 1388-9842 SB - IM CY - Netherlands
Keywords: ACT, ACTIVATION, antagonists & inhibitors, As, cardiac, CARDIAC MYOCYTES, Depression, Chemical, disease, DONOR, DONORS, drug effects, EC, EFFECTOR, effects, Endocardium, endogenous, Enzyme Induction, function, functional, health, heart, HUMAN MYOCARDIUM, IM, INDUCTION, isoform, kinetic, Kinetics, LA, LEVEL, Lung, May, metabolism, Myocardial Contraction, Myocardium, myocytes, negative, Netherlands, nitric oxide, Nitric Oxide Donors, nitric oxide synthase, NITRIC-OXIDE, Nitric-Oxide Synthase, NO+, NUMBER, OUTPUT, OXIDE, pharmacology, physiology, play, positive, Preparation, PUBLISHED, RANGE, release, REMAINS, response, Review, rodent, Role, STATE, STATES, Stimulation, Chemical, subcellular, Support, Non-U.S.Gov't, SYNTHASE, SYSTEM, target, targeting, targets, therapeutic
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
URI: http://discovery.ucl.ac.uk/id/eprint/27333
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