Inflammatory bowel disease and laterality: is left handedness a risk?
BACKGROUND: Left handedness has been associated with inflammatory bowel disease (IBD) and autoimmune diseases. AIMS: To determine whether left handedness is associated with IBD in two prospective national birth cohorts. METHODS: Subjects with Crohn's disease (CD) and ulcerative colitis (UC) were identified from two national longitudinal birth cohorts at age 26 years (1970 British Cohort Study (BCS70), born in 1970) and age 33 years (National Child Development Study (NCDS), born in 1958). Laterality was determined at age 10 (BCS70) or seven (NCDS) years, based on hand preference for writing and foot preference for kicking a ball (BCS70 only). Multiple logistic regression was used to assess the relationship of handedness with CD, UC, and IBD in the cohorts combined and adjusted for sex. RESULTS: Both cohorts combined showed increased adjusted relative odds of 2.13 (95% confidence interval (CI) 0.97--4.65; p=0.059), 2.13 (95% CI 0.92--4.91; p=0. 077), and 2.13 (95% CI 1.20--3.78; p=0.010) for CD, UC, and IBD, respectively in left handers. CONCLUSIONS: The study suggests a link between IBD and left handedness which may be genetic and/or environmental in origin
|Title:||Inflammatory bowel disease and laterality: is left handedness a risk?|
|Additional information:||UI - 21347597 LA - eng PT - Journal Article DA - 20010716 IS - 0017-5749 SB - AIM SB - IM CY - England|
|Keywords:||age, Association, autoimmune, autoimmune disease, Autoimmune Diseases, AUTOIMMUNE-DISEASE, AUTOIMMUNE-DISEASES, BEHAN-GALABURDA MODEL, BIRTH, BORN, bowel, BOWEL DISEASE, BOWEL-DISEASE, British, CEREBRAL LATERALIZATION, Child, Child Development, COHORT, Cohort Studies, cohort study, colitis, confidence, confidence interval, Crohn's disease, CROHNS-DISEASE, ct, development, disease, Diseases, Disorders, English, environmental, genetic, Gut, Hand, HAND PREFERENCE, handedness, IBD, INFLAMMATORY BOWEL DISEASE, INFLAMMATORY-BOWEL-DISEASE, Laterality, Left, link, Logistic Regression, Longitudinal, May, MED, Methods, multiple, NATIONAL BIRTH COHORT, ORIGIN, Prevalence, REGRESSION, relationship, Relative, Result, Risk, Sex, SWEDEN, UC, ulcerative colitis, ULCERATIVE-COLITIS, Writing, adult, age, Colitis, Ulcerative, Confidence Intervals, Crohn Disease, etiology, Female, IM, LA, Logistic Models, Male, Odds Ratio, Risk Factors, Sex Factors, Support, Non-U.S.Gov't|
|UCL classification:||UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
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