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A mouse model of Streptococcus pneumoniae meningitis mimicking several features of human disease

Gerber, J; Raivich, G; Wellmer, A; Noeske, C; Kunst, T; Werner, A; Bruck, W; (2001) A mouse model of Streptococcus pneumoniae meningitis mimicking several features of human disease. ACTA NEUROPATHOL , 101 (5) 499 - 508.

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Abstract

The course of bacterial titers, meningeal inflammation, behavioral abnormalities, and neuronal damage was studied in a mouse model of Streptococcus pneumoniae meningitis. At 24 h after injection of 10(4) colony-forming units (CFU) S. pneumoniae into the right forebrain, infected mice became severely lethargic. Bacterial titers in cerebrospinal fluid and cerebellum rose to 10(9) CFU/ml, with strong granulocyte invasion into the meninges and neuronal necroses in the neocortex, striatum and hippocampal formation. Meningeal inflammation and neuronal damage in intercellular cell adhesion molecule-1- and macrophage colony-stimulating factor-deficient mice was similar to that in wild-type litrermates. Untreated, the infection was fatal. Wild-type mice treated earlier than 24 h after infection with ceftriaxone (2 mg every 12 h for 3 days) survived without apparent behavioral abnormalities. Delay of treatment beyond 30 h led to the death of more than 50% of the infected mice. This mouse model is suitable fur therapeutic studies and for the investigation of inflammation in knockout mice. The neuronal damage resembles morphological abnormalities observed in humans.

Type: Article
Title: A mouse model of Streptococcus pneumoniae meningitis mimicking several features of human disease
Keywords: ceftriaxone, intercellular cell adhesion molecule-1-deficient mice, inflammation, meningitis, Streptococcus pneumoniae, EXPERIMENTAL PNEUMOCOCCAL MENINGITIS, INTERCELLULAR-ADHESION MOLECULE-1, FACIAL MOTOR NUCLEUS, BACTERIAL-MENINGITIS, MENINGEAL MACROPHAGES, MONOCLONAL-ANTIBODY, CEREBROSPINAL-FLUID, NERVOUS-SYSTEM, DENTATE GYRUS, RAT-BRAIN
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health > Maternal and Fetal Medicine
URI: http://discovery.ucl.ac.uk/id/eprint/26496
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