White, RP and Deane, C and Hindley, C and Bloomfield, PM and Cunningham, VJ and Vallance, P and Brooks, DJ and Markus, HS (2000) The effect of the nitric oxide donor glyceryl trinitrate on global and regional cerebral blood flow in man. Journal of the Neurological Sciences , 178 (1) 23 - 28.
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Despite their potential use as cerebral vasodilatory agents there are few studies of the effect of nitric oxide (NO) donors on the cerebral circulation in non-anaesthetised man. We determined the effect of the NO donor glyceryl trinitrate (GTN) at clinically relevant doses on global and regional cerebral blood flow (CBF) in healthy non- anaesthetised volunteers, using H(2)(15)O PET, ultrasonic colour velocity flow imaging of carotid artery flow, and transcranial Doppler (TCD) of middle cerebral artery velocities (MCAv). Three rates of GTN infusion (0.1, 0.4, 1.0 microg/kg/min) were used. There was no significant change in common or internal carotid artery flow following GTN administration although a dose dependent fall in MCAv post GTN was observed. There was no significant change in either global or regional CBF following GTN. Thus intravenous GTN at therapeutic doses in awake humans does not alter global or regional CBF. However it does produce basal cerebral artery vasodilatation as evidenced by a fall in MCAv in the absence of a change in internal carotid artery flow
|Title:||The effect of the nitric oxide donor glyceryl trinitrate on global and regional cerebral blood flow in man|
|Keywords:||ABSENCE, Administration, adult, Aged, AGENTS, Analysis of Variance, Arteries, artery, As, Blood, blood flow, Blood Flow Velocity, Carotid Artery, Internal, Cerebral, cerebral arteries, cerebral artery, Cerebrovascular Circulation, CIRCULATION, clinical, colour, COMMON, DONORS, DOPPLER, drug effects, Female, flow, global, HEALTHY, HUMANS, imaging, INFUSION, Male, medicine, Middle Age, Middle Cerebral Artery, neuroscience, nitric oxide, Nitric Oxide Donors, NITRIC-OXIDE, Nitroglycerin, OXIDE, PET, pharmacology, physiology, psychiatry, Support, Non-U.S.Gov't, therapeutic, Tomography, Emission-Computed, UK, ultrasonic, Ultrasonics, Ultrasonography, Vasodilator Agents|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)|
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