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Endophenotype approach to developmental psychopathology: Implications for autism research

Viding, E; Blakemore, SJ; (2007) Endophenotype approach to developmental psychopathology: Implications for autism research. BEHAV GENET , 37 (1) 51 - 60. 10.1007/s10519-006-9105-4.

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Abstract

This paper discusses the utility of the endophenotype approach in the study of developmental psychopathology. It is argued that endophenotype research holds considerable promise for the study of gene-brain/cognition-behaviour pathways for developmental disorders. This paper outlines the criteria for determining useful endophenotypes. Possible endophenotypes for autism are discussed as an example of an area where endophenotype research on developmental disorders may be fruitful. It is concluded that although the endophenotype approach holds promise for the study of gene-brain/cognition-behaviour pathways, much work remains to be done in order to validate endophenotype measures. It is also noted that the changing nature of any developmental psychopathology poses a particular challenge to this type of research.

Type: Article
Title: Endophenotype approach to developmental psychopathology: Implications for autism research
DOI: 10.1007/s10519-006-9105-4
Keywords: intermediate phenotype, cognitive development, autism, Asperger syndrome, theory of mind, mentalising, central coherence, CATECHOL-O-METHYLTRANSFERASE, WEAK CENTRAL COHERENCE, SPECTRUM DISORDERS, NEURAL MECHANISMS, ASPERGER-SYNDROME, INDIVIDUAL-DIFFERENCES, COGNITIVE PHENOTYPE, MIND, CHILDREN, BRAIN
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience
URI: http://discovery.ucl.ac.uk/id/eprint/2567
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