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Risk of second malignancy after Hodgkin's disease in a collaborative British cohort: the relation to age at treatment.
Journal of Clinical Oncology
498 - 509.
PURPOSE: To assess long-term site-specific risks of second malignancy after Hodgkin's disease in relation to age at treatment and other factors. PATIENTS AND METHODS: A cohort of 5,519 British patients with Hodgkin's disease treated during 1963 through 1993 was assembled and followed-up for second malignancy and mortality. Follow-up was 97% complete. RESULTS: Three hundred twenty-two second malignancies occurred. Relative risks of gastrointestinal, lung, breast, and bone and soft tissue cancers, and of leukemia, increased significantly with younger age at first treatment. Absolute excess risks and cumulative risks of solid cancers and leukemia, however, were greater at older ages than at younger ages. Gastrointestinal cancer risk was greatest after mixed-modality treatment (relative risk [RR] = 3.3; 95% confidence interval [CI], 2.1 to 4.8); lung cancer risks were significantly increased after chemotherapy (RR = 3. 3; 95% CI, 2.4 to 4.7), mixed-modality treatment (RR = 4.3; 95% CI, 2.9 to 6.2), and radiotherapy (RR = 2.9; 95% CI, 1.9 to 4.1); breast cancer risk was increased only after radiotherapy without chemotherapy (RR = 2.5; 95% CI, 1.4 to 4.0); and leukemia risk was significantly increased after chemotherapy (RR = 31.6; 95% CI, 19.7 to 47.6) and mixed-modality treatment (RR = 38.1; 95% CI, 24.6 to 55. 9). These risks were generally greater after treatment at younger ages: for patients treated at ages younger than 25 years, there were RRs of 18.7 (95% CI, 5.8 to 43.5) for gastrointestinal cancer after mixed-modality treatment, 14.4 (95% CI, 5.7 to 29.3) for breast cancer after radiotherapy, and 85.2 (95% CI, 45.3 to 145.7) for leukemia after chemotherapy (with or without radiotherapy). CONCLUSION: Age at treatment has a major effect on risk of second malignancy after Hodgkin's disease. Although absolute excess risks are greater for older patients, RRs of several important malignancies are much greater for patients who are treated when young. The increased risk of gastrointestinal cancers may relate particularly to mixed-modality treatment, and that of lung cancer to chemotherapy as well as radiotherapy; there are also well-known increased risks of breast cancer from radiotherapy and leukemia from chemotherapy. The roles of specific chemotherapeutic agents in the etiology of solid cancers after Hodgkin's disease require detailed investigation
|Title:||Risk of second malignancy after Hodgkin's disease in a collaborative British cohort: the relation to age at treatment|
|Additional information:||UI - 20120868 DA - 20000229 IS - 0732-183X LA - eng PT - Journal Article CY - UNITED STATES JC - JCO SB - IM|
|Keywords:||Adolescence, adult, age, Age Factors, AGENTS, As, bone, Breast, BREAST CANCER, British, cancer, cancers, Chemotherapy, COHORT, Cohort Studies, Combined Modality Therapy, Complete, CRC, disease, drug therapy, epidemiology, etiology, factors, Female, FOLLOW UP, Follow-up, Gastrointestinal, Great Britain, health, Hodgkin Disease, Hodgkin's disease, Leukemia, Lung, Lung cancer, Male, MALIGNANCIES, May, medicine, Methods, Middle Age, MORTALITY, Neoplasms, Second Primary, Other, pathology, Patient, patients, population, Radiotherapy, Risk, Risk Factors, risks, Soft-tissue, STATE, STATES, Support, Non-U.S.Gov't, Time Factors, Tissue, treatment, United States, Young|
|UCL classification:||UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Statistical Science|
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