Lombardo, F; Shalaeva, MY; Tupper, KA; Gao, F; Abraham, MH; (2000) ElogPoct: a tool for lipophilicity determination in drug discovery. J Med Chem , 43 (15) 2922 - 2928.
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We present an RP-HPLC method, for the determination of logPoct values for neutral drugs, which combines ease of operation with high accuracy and which has been shown to work for a set of 36 molecules comprised largely of drugs. The general features of the method are as follows: (i) compound sparing (< or = 1 mL of a 30-50 microg/mL solution needed), (ii) rapid determinations (20 min on average), (iii) low sensitivity to impurities, (iv) wide lipophilicity range (6 logPoct units), (v) good accuracy, (vi) excellent reproducibility. A linear free energy relationship (LFER) analysis, based on solvation parameters, shows that the method encodes the same information obtained from a shake-flask logPoct determination. To the best of our knowledge a similar performance, on a set of noncongeneric drugs, has not been previously reported. We refer to the value generated via this method as ElogPoct.
|Title:||ElogPoct: a tool for lipophilicity determination in drug discovery.|
|Keywords:||1-Octanol, Chromatography, High Pressure Liquid, Pharmaceutical Preparations, Solubility, Solvents|
|UCL classification:||UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry|
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