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Transcription factors as potential targets for therapeutic drugs.

Latchman, DS; (2000) Transcription factors as potential targets for therapeutic drugs. Curr Pharm Biotechnol , 1 (1) pp. 57-61.

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Abstract

Although drugs which target transcription are in wide therapeutic use, they were all identified on the basis of their effect on a specific biological process such as inflammation or hormone responses and were only subsequently shown to target transcription. Our recent progress in understanding the mechanism of action of these drugs and the mechanisms of transcriptional regulation in general offers hope for a new generation of drugs isolated on the basis of their ability to modulate either the synthesis of transcription factors, the regulation of their activity by ligands or phosphorylation events, their protein-protein interactions or their binding to DNA.

Type: Article
Title: Transcription factors as potential targets for therapeutic drugs.
Location: Netherlands
Keywords: Animals, Gene Expression, Humans, Transcription Factors
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH - Directors Office
URI: http://discovery.ucl.ac.uk/id/eprint/24860
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