Tisdall, M.M.;
Tachtsidis, I.;
Leung, T.S.;
Elwell, C.E.;
Smith, M.;
(2007)
Near infrared spectroscopic quantification of changes in the concentration of oxidized cytochrome oxidase in the healthy human brain during hypoxemia.
Journal of Biomedical Optics
, 12
(2)
024002-1.
10.1117/1.2718541.
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Abstract
The near infrared cytochrome c oxidase (CCO) signal has potential as a clinical marker of changes in mitochondrial oxygen utilization. We examine the CCO signal response to reduced oxygen delivery in the healthy human brain. We induced a reduction in arterial oxygen saturation from baseline levels to 80% in eight healthy adult humans, whilst minimising changes in end tidal carbon dioxide tension. We measured changes in the cerebral concentrations of oxidized CCO (Δ[oxCCO]), oxy-hemoglobin (Δ[HbO2]) and deoxy-hemoglobin (Δ[HHb]) using broadband near infrared spectroscopy (NIRS), and estimated changes in cerebral oxygen delivery (ecDO2) using pulse oximetry and transcranial Doppler ultrasonography. Results are presented as median (interquartile range). At the nadir of hypoxemia ecDO2 decreased by 9.2(5.4-12.1)% (p<0.0001), Δ[oxCCO] decreased by 0.24(0.06-0.28) micromoles/l (p<0.01), total hemoglobin concentration increased by 2.83(2.27-4.46) micromoles/l (p<0.0001) and change in haemoglobin difference concentration (Δ[Hbdiff]=Δ[HbO2]-Δ[HHb]) decreased by 12.72(11.32-16.84) micromoles/l (p<0.0001). Change in ecDO2 correlated with Δ[oxCCO] (r=0.78, p<0.001), but not with either change in total hemoglobin concentration or Δ[Hbdiff]. This is the first description of cerebral Δ[oxCCO] during hypoxemia in healthy adults. Studies are ongoing to investigate the clinical relevance of this signal in patients with traumatic brain injury.
| Type: | Article |
|---|---|
| Title: | Near infrared spectroscopic quantification of changes in the concentration of oxidized cytochrome oxidase in the healthy human brain during hypoxemia |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1117/1.2718541 |
| Publisher version: | http://dx.doi.org/doi:10.1117/1.2718541 |
| Language: | English |
| Additional information: | Copyright 2007 Society of Photo-Optical Instrumentation Engineers. This paper was published in Journal of Biomedical Optics and is made available as an electronic reprint with permission of SPIE. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. |
| Keywords: | cytochrome c oxidase, near infrared spectroscopy, cerebral monitoring |
| UCL classification: | UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/2476 |
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