UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Changes in metabolism of rat kidney and liver caused by experimental diabetes and by dietary sucrose.

Kang, SS; Fears, R; Noirot, S; Mbanya, JN; Yudkin, J; (1982) Changes in metabolism of rat kidney and liver caused by experimental diabetes and by dietary sucrose. Diabetologia , 22 (4) pp. 285-288.

Full text not available from this repository.

Abstract

Two groups of rats were fed diets in which the carbohydrate components was either starch or sucrose. A third group was fed on a stock diet. Half of the animals in each group were made diabetic by injection of either streptozotocin, in two of the groups, or alloxan, in the third group. Both diabetes and sucrose-feeding increased renal gluconeogenesis as indicated by increased activities of fructose-1,6-diphosphatase and glucose-6-phosphatase. Sucrose-feeding increased fatty acid synthesis both in the liver and kidney. However, the effect of diabetes on fatty acid synthesis was different at the two tissue sites. Diabetes, whether induced by streptozotocin or alloxan, decreased fatty acid synthesis in the liver but increased the rate in the kidney. The latter response was obtained for each diet but was additive with the effect of sucrose. We conclude that the effect of diabetes on renal lipid metabolism may reflect, in part, the accelerated glucose flux. The response to both diabetes and sucrose-feeding is also possibly associated with the increased lipid required for the membrane synthesis reported previously.

Type: Article
Title: Changes in metabolism of rat kidney and liver caused by experimental diabetes and by dietary sucrose.
Location: Germany
Keywords: Animals, Body Weight, Diabetes Mellitus, Experimental, Dietary Carbohydrates, Fatty Acids, Kidney, Liver, Male, Organ Size, Rats, Rats, Inbred Strains, Starch, Sucrose
URI: http://discovery.ucl.ac.uk/id/eprint/24230
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item