Application of chemically induced dynamic nuclear polarization to the nitration of N-acetyltyrosine and to some reactions of peroxynitrite.
By the observation of chemically induced dynamic nuclear polarization in N-15 NMR spectroscopy it has been shown that nitration of N-acetyltyrosine, even render acidic conditions, is largely a radical process. In the alkaline reaction of tyrosine with peroxynitrite the main products are nitrite and nitrate, both produced by a radical pathway, and tyrosine nitration is a minor reaction. It is suggested that tyrosine catalyzes the production of NOS and HO. from peroxgnitrite. (C) 2000 Academic Press
|Title:||Application of chemically induced dynamic nuclear polarization to the nitration of N-acetyltyrosine and to some reactions of peroxynitrite|
|Additional information:||Journal Article OCT 366QP Butler AR Univ St Andrews, Sch Chem, Ctr Biomol Sci, St Andrews KY16 9ST, Fife, Scotland NITRIC OXIDE-BIOL CHEM|
|Keywords:||ACID, ADDUCT, Ar, chemically induced, chemistry, DECOMPOSITION, dynamic, mechanisms, N-15 CIDNP, N-15 NMR, nitric oxide, NITRIC-OXIDE, NMR, NOS, nuclear, nuclear polarization, PATHWAY, peroxynitrite, process, processes, product, radicals, Scotland, spectroscopy, SUPEROXIDE-DISMUTASE, Tyrosine, TYROSINE NITRATION|
|UCL classification:||UCL > School of BEAMS
UCL > School of BEAMS > Faculty of Maths and Physical Sciences
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