UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Posttransplantation prevention and treatment of recurrent hepatitis C.

Burroughs, AK; (2000) Posttransplantation prevention and treatment of recurrent hepatitis C. Liver Transpl , 6 (6 Supp) S35-S40. 10.1053/jlts.2000.18690.

Full text not available from this repository.

Abstract

Hepatitic C virus (HCV) viremia is universal after orthotopic liver transplantation (OLT) for HCV cirrhosis. 2. At 5 years post-OLT, approximately 20% of patients have cirrhosis caused by recurrent hepatitis C. 3. Progression of disease is related to immunosuppression, immune response (CD4(+) lymphocytes), HCV genotype, and HCV quasispecies homogeneity. 4. Whether a therapeutic strategy of pre-OLT or early (preemptive) antiviral therapy is better than treating a clinically important hepatitis and the duration of treatment are not known. 5. Monotherapy with recombinant interferon-alpha or ribavirin is not useful in the long term. 6. Combination therapy (interferon and ribavirin) has given better results, but long-term data are not available. 7. HCV recurrence will benefit from randomized studies.

Type: Article
Title: Posttransplantation prevention and treatment of recurrent hepatitis C.
Location: UNITED STATES
DOI: 10.1053/jlts.2000.18690
Keywords: Anti-Inflammatory Agents, Antiviral Agents, Calcineurin Inhibitors, Disease Progression, Drug Therapy, Combination, Hepatitis C, Chronic, Humans, Immunosuppressive Agents, Liver Transplantation, Recurrence, Steroids
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)
URI: http://discovery.ucl.ac.uk/id/eprint/24081
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item