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Connection between chromatographic data and biological data

Abraham, MH; Gola, JMR; Kumarsingh, R; Cometto-Muniz, JE; Cain, WS; (2000) Connection between chromatographic data and biological data. Journal of Chromatography B: Biomedical Sciences and Applications , 745 (1) 103 - 115.

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Abstract

There are no previous references to the direct use of GLC data in the correlation of biological processes, but we show that GLC retention data can be used in the correlation of several such processes involving gaseous solutes. There are a number of reports of RP-HPLC and MEKC data being used in the correlation of biological processes, but they are mostly restricted as to the number and type of solute studied. We show that if chromatographic data are used to obtain solvation descriptors for solutes, and if these descriptors are then used in the correlation of biological processes, that this indirect connection is a much more powerful and generally applicable method than is the direct connection between chromatographic data and biological data. (C) 2000 Elsevier Science B.V. All rights reserved

Type:Article
Title:Connection between chromatographic data and biological data
Additional information:Journal Article AUG 4 345HM Abraham MH Univ London Univ Coll, Dept Chem, 20 Gordon St, London WC1H 0AJ, England J CHROMATOGR B
Keywords:ANESTHETIC TARGET SITES, ARTIFICIAL MEMBRANE COLUMN, As, BRAIN PENETRATION, DESCRIPTORS, GAS-LIQUID-CHROMATOGRAPHY, HYDROPHOBICITY PARAMETER, IRRITATION THRESHOLDS, MICELLAR ELECTROKINETIC CHROMATOGRAPHY, NASAL PUNGENCY THRESHOLDS, REVERSED-PHASE, Science, SOLUBILITY FACTORS, SOLUTE, SOLUTES, SOLVATION, solvation descriptors
UCL classification:UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry

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