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Purinergic mechanosensory transduction and visceral pain

Burnstock, G; (2009) Purinergic mechanosensory transduction and visceral pain. Molecular Pain , 5 , Article 69. 10.1186/1744-8069-5-69. Green open access


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In this review, evidence is presented to support the hypothesis that mechanosensory transduction occurs in tubes and sacs and can initiate visceral pain. Experimental evidence for this mechanism in urinary bladder, ureter, gut, lung, uterus, tooth-pulp and tongue is reviewed. Potential therapeutic strategies are considered for the treatment of visceral pain in such conditions as renal colic, interstitial cystitis and inflammatory bowel disease by agents that interfere with mechanosensory transduction in the organs considered, including P2X(3) and P2X(2/3) receptor antagonists that are orally bioavailable and stable in vivo and agents that inhibit or enhance ATP release and breakdown.

Type: Article
Title: Purinergic mechanosensory transduction and visceral pain
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/1744-8069-5-69
Publisher version: http://dx.doi.org/10.1186/1744-8069-5-69
Language: English
Additional information: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Irritable-bowel-syndrome, Enteric nervous-system, Rat taste-buds, Sensory neurons, Urinary-bladder, P2X receptors, ATP release, Guinea-pig, Adenosine-triphosphate, Dorsal-root
URI: http://discovery.ucl.ac.uk/id/eprint/23443
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