Burnstock, G; (2009) Purinergic mechanosensory transduction and visceral pain. Molecular Pain , 5 , Article 69. 10.1186/1744-8069-5-69.
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In this review, evidence is presented to support the hypothesis that mechanosensory transduction occurs in tubes and sacs and can initiate visceral pain. Experimental evidence for this mechanism in urinary bladder, ureter, gut, lung, uterus, tooth-pulp and tongue is reviewed. Potential therapeutic strategies are considered for the treatment of visceral pain in such conditions as renal colic, interstitial cystitis and inflammatory bowel disease by agents that interfere with mechanosensory transduction in the organs considered, including P2X(3) and P2X(2/3) receptor antagonists that are orally bioavailable and stable in vivo and agents that inhibit or enhance ATP release and breakdown.
|Title:||Purinergic mechanosensory transduction and visceral pain|
|Open access status:||An open access publication. A version is also available from UCL Discovery.|
|Additional information:||This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.|
|Keywords:||Irritable-bowel-syndrome, Enteric nervous-system, Rat taste-buds, Sensory neurons, Urinary-bladder, P2X receptors, ATP release, Guinea-pig, Adenosine-triphosphate, Dorsal-root|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)|
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