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Protein structural topology: Automated analysis and diagrammatic representation

Westhead, DR; Slidel, TW; Flores, TP; Thornton, JM; (1999) Protein structural topology: Automated analysis and diagrammatic representation. Protein Science , 8 (4) 897 - 904.

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Abstract

The topology of a protein structure is a highly simplified description of its fold including only the sequence of secondary structure elements, and their relative spatial positions and approximate orientations. This information can be embodied in a two-dimensional diagram of protein topology, called a TOPS cartoon. These cartoons are useful for the understanding of particular folds and making comparisons between folds. Here we describe a new algorithm for the production of TOPS cartoons, which is more robust than those previously available, and has a much higher success rate. This algorithm has been used to produce a database of protein topology cartoons that covers most of the data bank of known protein structures

Type:Article
Title:Protein structural topology: Automated analysis and diagrammatic representation
Additional information:UI - 99226818 LA - Eng PT - JOURNAL ARTICLE DA - 19990714 IS -0961-8368 SB - M CY - UNITED STATES JC - BNW AA - Author EM -199909
Keywords:Proteins, analysis, United States, Algorithms, bioinformatics, Chemistry, Physical, Computer Simulation, database, Genome, Methods, Models, Chemical, Models, Molecular, Protein Conformation, Protein Structure, Software, Structure
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)

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