UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Signaling by distinct classes of phosphoinositide 3-kinases.

Vanhaesebroeck, B; Waterfield, MD; (1999) Signaling by distinct classes of phosphoinositide 3-kinases. Exp Cell Res , 253 (1) 239 - 254. 10.1006/excr.1999.4701.

Full text not available from this repository.

Abstract

Many signaling pathways converge on and regulate phosphoinositide 3-kinase (PI3K) enzymes whose inositol lipid products are key mediators of intracellular signaling. Different PI3K isoforms generate specific lipids that bind to FYVE and pleckstrin homology (PH) domains in a variety of proteins, affecting their localization, conformation, and activities. Here we review the activation mechanisms of the different types of PI3Ks and their downstream actions, with focus on the PI3Ks that are acutely triggered by extracellular stimulation.

Type:Article
Title:Signaling by distinct classes of phosphoinositide 3-kinases.
Location:UNITED STATES
DOI:10.1006/excr.1999.4701
Language:English
Keywords:Animals, Binding Sites, Isoenzymes, Mice, Mice, Knockout, Phosphatidylinositol 3-Kinases, Protein Structure, Tertiary, Protein-Serine-Threonine Kinases, Signal Transduction
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Wolfson Institute and Cancer Institute Administration > Cancer Institute > Research Department of Oncology

Archive Staff Only: edit this record