Vanhaesebroeck, B; Waterfield, MD; (1999) Signaling by distinct classes of phosphoinositide 3-kinases. Exp Cell Res , 253 (1) 239 - 254. 10.1006/excr.1999.4701.
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Many signaling pathways converge on and regulate phosphoinositide 3-kinase (PI3K) enzymes whose inositol lipid products are key mediators of intracellular signaling. Different PI3K isoforms generate specific lipids that bind to FYVE and pleckstrin homology (PH) domains in a variety of proteins, affecting their localization, conformation, and activities. Here we review the activation mechanisms of the different types of PI3Ks and their downstream actions, with focus on the PI3Ks that are acutely triggered by extracellular stimulation.
|Title:||Signaling by distinct classes of phosphoinositide 3-kinases.|
|Keywords:||Animals, Binding Sites, Isoenzymes, Mice, Mice, Knockout, Phosphatidylinositol 3-Kinases, Protein Structure, Tertiary, Protein-Serine-Threonine Kinases, Signal Transduction|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)|
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Wolfson Institute and Cancer Institute Administration > Cancer Institute > Research Department of Oncology
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