Smith, A and Alrubaie, S and Coehlo, C and Leevers, SJ and Ashworth, A (1999) Alternative splicing of the Drosophila PTEN gene. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression , 1447 (2-3) 313 - 317. 10.1016/S0167-4781(99)00172-4.
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Abstract
Mutations in the human PTEN gene have been identified in a number of different tumour types, and in the hamartomatous polyposis syndromes Cowden disease and Bannayan-Zonana syndrome. The PTEN gene encodes a phosphatase that antagonises phosphoinositide 3-kinase (PI3K) signalling by removing the 3' phosphate from phosphatidylinositol 3, 4,5-trisphosphate (PtdIns (3,4,5)P(3)). Here we show that the PTEN gene is conserved in the invertebrate Drosophila melanogaster and demonstrate that the gene undergoes alternative splicing
| Type: | Article |
|---|---|
| Title: | Alternative splicing of the Drosophila PTEN gene |
| DOI: | 10.1016/S0167-4781(99)00172-4 |
| Additional information: | UI - 20011294 LA - Eng RN - EC 2.7.1.137 (1-Phosphatidylinositol 3-Kinase) RN - EC 3.1.3 (Phosphoric Monoester Hydrolases) RN - EC 3.1.3.- (PTEN protein) PT - JOURNAL ARTICLE DA - 19991208 IS -0006-3002 SB - M SB - X CY - NETHERLANDS JC - A0W AA - Author EM -200002 |
| Keywords: | Alternative Splicing, Drosophila, GENE, 1-Phosphatidylinositol 3-Kinase, Phosphoric Monoester Hydrolases, PTEN protein, Proteins, 1 Phosphatidylinositol 3 Kinase, Amino Acid Sequence, Animal, cancer, Drosophila melanogaster, Evolution, Molecular, Genes, Insect, Genes, Suppressor, Tumor, genetics, Molecular Sequence Data, Mutation, phosphoinositide, phosphoinositide 3-kinase, PtdIns, Sequence Alignment, Phosphatidylinositols |
| UCL classification: | UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of) |
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