Mabile, L and Bruckdorfer, KR and Rice-Evans, C (1999) Moderate supplementation with natural alpha-tocopherol decreases platelet aggregation and low-density lipoprotein oxidation 2. Atherosclerosis , 147 (1) 177 - 185.
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Previous studies have shown that oral administration of 300 mg alpha- tocopherol/day to healthy volunteers decreases platelet function and enhances their sensitivity to the platelet inhibitor, prostaglandin E(1), when full dose-response curves to a range of agonist concentrations are made. In this study, the effects of oral doses of natural alpha-tocopherol (75, 200 and 400 IU/day) were studied in order to determine whether the same effects might be achieved with lower intakes of vitamin E and whether inhibition is related to the platelet levels of the antioxidant in platelet membranes. Twenty two subjects undertook the supplementation regime, divided into three units of 2 weeks, each cycling through each of the dosages. The results show that uptake of vitamin E by the platelets was optimal at 75 IU/day, correlating with the maximal influence on platelet aggregation and platelet responsiveness to inhibition by PGE1, increased supplemental levels exerting no greater effects
|Title:||Moderate supplementation with natural alpha-tocopherol decreases platelet aggregation and low-density lipoprotein oxidation 2|
|Additional information:||UI - 99454619 LA - Eng RN - 0 (beta-Thromboglobulin) RN - 0 (Lipids) RN - 0 (Lipoproteins) RN - 0 (Lipoproteins, LDL) RN - 0 (Platelet Aggregation Inhibitors) RN - 1406-18-4 (Vitamin E) RN -56-65-5 (Adenosine Triphosphate) RN - 745-65-3 (Alprostadil) PT -JOURNAL ARTICLE DA - 19991124 IS - 0021-9150 SB - M CY - IRELAND JC - 95X AA - Author EM - 200001|
|Keywords:||Lipoproteins, Lipids, Vitamin E, Adenosine, Adenosine Triphosphate, administration & dosage, Administration, Oral, Adult, Alprostadil, beta-Thromboglobulin, blood, Blood Platelets, Dose-Response Relationship, Drug, drug effects, Female, Lipoproteins, LDL, Male, metabolism, Middle Age, Oxidation-Reduction, pharmacology, Platelet Aggregation, Platelet Aggregation Inhibitors, secretion, Support, Non-U.S.Gov't, function, agonists, Antioxidants|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)|
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