Leevers, SJ; Vanhaesebroeck, B; Waterfield, MD; (1999) Signalling through phosphoinositide 3-kinases: the lipids take centre stage. Curr Opin Cell Biol , 11 (2) 219 - 225.
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Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids at the 3' position of the inositol ring to generate the 3-phosphoinositides PI(3)P, PI(3,4) P2 and PI(3,4,5) P3. Recent research has shown that one way in which these lipids function in signal transduction and membrane trafficking is by interacting with 3-phosphoinositide-binding modules in a broad variety of proteins. Specifically, certain FYVE domains bind PI(3)P whereas certain pleckstrin homology domains bind PI(3,4) P2 and/or PI(3,4,5) P3. Also in 1998, PTEN - a major tumour suppressor in human cancer - was also shown to antagonise PI3K signalling by removing the 3-phosphate from 3-phosphoinositides.
|Title:||Signalling through phosphoinositide 3-kinases: the lipids take centre stage.|
|Keywords:||Amino Acid Sequence, Animals, Blood Proteins, Enzyme Activation, GTP-Binding Proteins, Genes, Tumor Suppressor, Humans, Isoenzymes, Membrane Lipids, Models, Biological, Neoplasm Proteins, PTEN Phosphohydrolase, Phosphatidylinositol 3-Kinases, Phosphatidylinositols, Phosphoproteins, Phosphoric Monoester Hydrolases, Phosphorylation, Protein Processing, Post-Translational, Protein-Tyrosine Kinases, Signal Transduction, Tumor Suppressor Proteins|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)|
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Wolfson Institute and Cancer Institute Administration > Cancer Institute > Research Department of Pathology
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