Leevers, SJ and Vanhaesebroeck, B and Waterfield, MD (1999) Signalling through phosphoinositide 3-kinases: the lipids take centre stage. Current Opinion in Cell Biology , 11 (2) 219 - 225.
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Abstract
Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids at the 3' position of the inositol ring to generate the 3-phosphoinositides PI(3)P, PI(3,4) P2 and PI(3,4,5) P3. Recent research has shown that one way in which these lipids function in signal transduction and membrane trafficking is by interacting with 3-phosphoinositide-binding modules in a broad variety of proteins. Specifically, certain FYVE domains bind PI(3)P whereas certain pleckstrin homology domains bind PI(3,4) P2 and/or PI(3,4, 5) P3. Also in 1998, P
| Type: | Article |
|---|---|
| Title: | Signalling through phosphoinositide 3-kinases: the lipids take centre stage |
| Additional information: | UI - 99227316 LA - Eng RN - EC 2.7.1.112 (Protein-Tyrosine Kinase) RN - EC 2.7.1.137 (1-Phosphatidylinositol 3-Kinase) RN -EC 3.1.3 (Phosphoric Monoester Hydrolases) RN - EC 3.1.3.- (PTEN protein) RN - EC 3.6.1.- (GTP-Binding Proteins) RN - 0 (platelet protein P47) RN - 0 (Blood Proteins) RN - 0 (Isoenzymes) RN - 0 (Membrane Lipids) RN - 0 (Neoplasm Proteins) RN - 0 (Phosphatidylinositols) PT - JOURNAL ARTICLE PT - REVIEW PT -REVIEW, TUTORIAL DA - 19990526 IS - 0955-0674 SB - M CY - UNITED STATES JC - AOE AA - Author EM - 199907 |
| Keywords: | phosphoinositide, phosphoinositide 3-kinase, Lipids, Protein-Tyrosine Kinase, 1-Phosphatidylinositol 3-Kinase, Proteins, GTP-Binding Proteins, platelet protein P47, blood, Blood Proteins, Isoenzymes, Membrane Lipids, Phosphatidylinositols, review, United States, 1 Phosphatidylinositol 3 Kinase, Amino Acid Sequence, Animal, Biochemistry, chemistry, classification, Enzyme Activation, Genes, Suppressor, Tumor, genetics, Models, Biological, Molecular Biology, Neoplasm Proteins, phosphoinositide 3-kinases, Phosphoric Monoester Hydrolases, Phosphorylation, physiology, Protein Processing, Post-Translational, Protein Tyrosine Kinase, PTEN protein, Signal Transduction, Support, Non-U.S.Gov't, function, homology |
| UCL classification: | UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of) |
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