Three-dimensional structure analysis of PROSITE patterns.
J Mol Biol
Pattern matches for each of the sequence patterns in PROSITE, a database of sequence patterns, were searched in all protein sequences in the Brookhaven Protein Data Bank (PDB). The three-dimensional structures of the pattern matches for the 20 patterns with the largest numbers of hits were analysed. We found that the true positives have a common three-dimensional structure for each pattern; the structures of false positives, found for six of the 20 patterns, were clearly different from those of the true positives. The results suggest that the true pattern matches each have a characteristic common three-dimensional structure, which could be used to create a template to define a three-dimensional functional pattern.
|Title:||Three-dimensional structure analysis of PROSITE patterns.|
|Keywords:||Adenosine Triphosphate, Amino Acid Sequence, Annexins, Aspartic Acid Endopeptidases, Conserved Sequence, Copper, Cytochrome c Group, Databases, Factual, False Positive Reactions, Guanosine Triphosphate, Models, Molecular, Pattern Recognition, Automated, Peroxidases, Protein Conformation, Proteins, RNA Ligase (ATP), Structure-Activity Relationship, Trypsin|
|UCL classification:||UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences
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