Vanhaesebroeck, B; Leevers, SJ; Panayotou, G; Waterfield, MD; (1997) Phosphoinositide 3-kinases: a conserved family of signal transducers. Trends Biochem Sci , 22 (7) 267 - 272.
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Phosphoinositide 3-kinases (PI3Ks) generate lipids that are implicated in receptor-stimulated signalling and in the regulation of membrane traffic. Several distinct classes of PI3Ks have now been identified that have been conserved throughout eukaryotic evolution. Potential signalling pathways downstream of PI3Ks have been elucidated and PI3K function is now being characterised in several model organisms.
|Title:||Phosphoinositide 3-kinases: a conserved family of signal transducers.|
|Keywords:||Animals, Caenorhabditis elegans, Dictyostelium, Drosophila melanogaster, Membrane Lipids, Molecular Sequence Data, Phosphatidylinositol 3-Kinases, Phosphotransferases (Alcohol Group Acceptor), Signal Transduction, Substrate Specificity|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)|
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Wolfson Institute and Cancer Institute Administration > Cancer Institute > Research Department of Pathology
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