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Mapping ESTs to the TSC1 candidate interval by use of the 'Science 96' transcript map

Wolfe, J; Stewart, H; McCulley, M; Grant, C; Naz, K; Jeremiah, S; ... Povey, S; + view all (1997) Mapping ESTs to the TSC1 candidate interval by use of the 'Science 96' transcript map. Annals of Human Genetics , 61 (5) 401 - 409. 10.1017/S0003480097006350.

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Abstract

The transcription map of the human genome published by Schuler et al. is a valuable resource in which approximately one quarter of all human genes have been mapped with respect to genetic framework markers using radiation hybrids. We have taken information from this map to provide potential genes within the TSC1 candidate region on chromosome 9q34. In so doing we have been able to provide an independent assay of the quality of the radiation hybrid mapping by using somatic cell hybrids and a 2 Mb cosmid contig covering the TSC1 region as mapping tools. In addition, we have built sequence contigs of ESTs for 25 clusters. This has shown that about 20% of the relevant EST clusters in the Unigene resource contain chimaeric clones.

Type:Article
Title:Mapping ESTs to the TSC1 candidate interval by use of the 'Science 96' transcript map
DOI:10.1017/S0003480097006350
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)

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