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A genome-wide screen for association in Hungarian multiple sclerosis

Rajda, C; Bencsik, K; Seres, E; Jonasdottir, A; Foltynie, T; Sawcer, S; Benediktsson, K; ... Vecsei, L; + view all (2003) A genome-wide screen for association in Hungarian multiple sclerosis. J NEUROIMMUNOL , 143 (1-2) 84 - 87. 10.1016/j.jneuroim.2003.08.017.

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Abstract

Although the pathogenesis of multiple sclerosis (MS) is not fully understood, substantial evidence points to the involvement of genetic factors. We report on a genome-wide screen for disease association in the Hungarian population using 5532 microsatellite markers. These markers were typed in DNA pools that consisted of 88 MS patients (cases), and 128 unrelated controls. Based on a stringent selection criterion, we obtained 33 markers suggesting association with the disease. (C) 2003 Elsevier B.V. All rights reserved.

Type: Article
Title: A genome-wide screen for association in Hungarian multiple sclerosis
DOI: 10.1016/j.jneuroim.2003.08.017
Keywords: multiple sclerosis, genome screen, linkage disequilibrium, SUSCEPTIBILITY, LINKAGE, PREVALENCE, POPULATION, RELATIVES, DISEASE, TWINS, RISKS, GENES, AGE
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Education
UCL > Provost and Vice Provost Offices > School of Education > UCL Institute of Education
UCL > Provost and Vice Provost Offices > School of Education > UCL Institute of Education > IOE - Social Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/21491
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